Some people say there is no point in trying to regulate cybermut. What Assignment

Emotions Free Essays

Collectivist nations Japan, china retreat feelings inborn to connection between the gatherings , Individualistic nations think feelings are not coordinated to them. Basic feelings : outrage, fear,sadness,happiness, appall, shock. Bliss Is mistaken for shock. We will compose a custom article test on Feelings or then again any comparative point just for you Request Now Love is hard to pass on In outward appearance. Positive feelings (Joy and appreciation) and negative feelings (outrage blame) . Unbiased state is non passionate. So in the event that we gathering and - eve feelings they become your mind-sets. Shock can not be placed in model comfortable its not satisfactory. High impact in temperament structure will identify with fervor. As same high - eve impact can be identified with apprehension, tense. What's more, some cross breed feelings, happiness blend of high +eve and low negative (quiet, loose). So these impacts shading our recognitions which becomes reality and conduct. Air entertainer model, Negative feelings negative disposition . Negative encounters are quick to remember. Positivist counterbalance If zero information generally individuals feel positive disposition. China has less of positive and negative feelings . Pride Is acceptable In US however no In china. Feelings help you to settle on levelheaded choices, mind Injury individuals settling on Irrational choices. Thinking + feeling objective choices. Wellsprings of feelings and temperaments 1. Character : ms strap and Hartmann Sings shows distinctive influence power 2. Time and day : +eve at end of week, negative at Sundays, in intra day positive state of mind tops during the center part . 3. Climate: deceptive relationship : when individuals think two things are connected at whatever point are not all that states of mind are not influenced by climate 4. Stress: unpleasant days influence states of mind adversely 5. Rest: poor/diminished rest cloud your choice and make hard to control our feelings 6. Exercise: +eve impact 7. Social effectively: 8. Age: passionate experience shows signs of improvement as we age, more +eve scene and less - eve 9. Sex: women’s responses are character based and men responses are condition Why we see more +eve mind-set at that point negative mind-sets 1. _eve feeling more when they are separated from everyone else 2. Hesitant to unveil - eve feeling in social circumstance Emotional work: individuals who need to communicate authoritative wanted feelings . Air entertainer Emotional discord : anticipating something different then sentiments Surface acting versus.. Profound acting (genuine inclination) ATE (full of feeling occasions hypothesis) : work place occasions causes passionate responses +eve and †e will impact working environment perspectives and practices. So individuals who score low on enthusiastic solidness respond emphatically to negative occasions. So every one of these impacts the COB, practices and working environment aberrance. 1 . Feelings give significant knowledge into how working environment bothers impact representative execution 2. Representative and administrators ought to onto disregard the feelings when they re minor as they collect. El is person’s capacity to see feelings in self and others,2, comprehend importance of feelings, manage feelings . Viable presidents US at that point bombed presidents the significant distinction was El. Contentions for El 1. Natural intrigue: Almost everybody concurs is a great idea to have social insight. Instinct is to distinguish feelings in others , control their feelings and handle social associations. Are acceptable in business world. 2. El predicts topic that elevated level of El implies individual will perform well hands on 3. El is organically based , individuals without particular cortex have same IQ however lower CEQ Arguments against El 1. El scientists don't concur on definition : some utilization tests before long utilize self reports 2. El can’t be estimated: proportions of El are immense 3. El is character yet with various name: El firmly identified with insight and character it has nothing extraordinary to offer. Enthusiastic Regulation: people with higher character characteristic of despondent people experience more difficulty to manage the feelings . What's more, individuals with low confidence are more averse to improve miserable disposition. Overlooking negative experience can prompt better guideline. Use of getting feelings and temperaments 1. Choice : factor in recruiting representatives, particularly in social connections. Better El better execution 2. Dynamic: +eve feelings prompting sound choices . Creativity:+I’ve temperament prompts inventiveness increasingly open in speculation 4. Inspiration : +eve mind-set prompts +eve criticism which fortifies the +eve disposition. Two gatherings puzzle model. Great to associate and higher deal for selling firm 5. Initiative : pioneer whenever energized eager will flock positive thinking delight . Help in elevating the vision to workers 6. Arrangement : so best moderator ought not feel awful about the negative feeling and create negative recognition for counter in part as that’s will weaken future exchange . SO Emotions can hinder mediator execution. So fire related crime fakes gage will be best exchange as he won't be reclaimed by negative results. 7. Client support: passionate cacophony can prompt decay of Job disappointment. Enthusiastic virus so +eve sentiment of representative will be reacted back +vela by client and lead to longer shopping. - eve feeling is additionally infectious 8. Employment disposition: awful day at work implies terrible night with your life partner . Individuals begrudge, outrage prompting freak conduct 10. Security and Injury at work. : - eve disposition can make you on edge, occupied and imprudent prompting injury. Chiefs use diversion and token of thankfulness to alleviate +eve mind-set Step by step instructions to refer to Emotions, Papers Feelings Free Essays Various individuals characterize feelings in various manners. Some make a differentiation among feelings and sentiments saying that an inclination is the reaction part of the feeling and that a feeling incorporates the circumstance or experience, the translation, the discernment, and the reaction or feeling identified with the experience of a specific circumstance. For the motivations behind this article, I utilize the terms conversely. We will compose a custom paper test on Feelings or on the other hand any comparable theme just for you Request Now John D. (Jack) Mayer says, â€Å"Emotions work on numerous levels. They have a physical viewpoint just as a mental perspective. Feelings connect thought, feeling, and activity †they work in all aspects of an individual, they influence numerous parts of an individual, and the individual influences numerous parts of the emotions.† Dr. Maurice Elias says, â€Å"Emotions are human beings’ cautioning frameworks concerning what is truly going on around them. Feelings are our most dependable pointers of how things are going on in our lives. Feelings help keep us destined for success by ensuring that we are driven by more than the psychological/scholarly resources of thought, observation, reason, memory.†  · Why Bother With Emotions: Feelings control your reasoning, conduct and activities. Feelings influence your physical bodies as much as your body influences your emotions and thinking. Individuals who overlook, excuse, subdue or simply ventilate their feelings, are setting themselves up for physical disease. Feelings that are not felt and discharged yet covered inside the body or in the emanation can cause genuine ailment, including disease, joint inflammation, and numerous sorts of constant sicknesses. Negative feelings, for example, dread, nervousness, antagonism, disappointment and sadness cause substance responses in your body that are altogether different from the synthetics discharged when you feel positive feelings, for example, cheerful, content, cherished, acknowledged.  · Belief Systems Basic quite a bit of our conduct is what is known as a conviction framework. This framework inside us channels what we see and hear, influencing how we carry on in our day by day lives. There are numerous different components that influence our lives,â including previous existences and the center issues we come into this life for goals, however our conviction frameworks in this life majorly affect what we think and do. Your conviction framework influences your recognitions or how you decipher what you see, hear and feel. For instance, an individual raised by an irate man or lady will see individuals later on with convictions that outrage is terrible or that it is something to fear. Another model would be somebody who is very savvy however who has never been empowered or regarded for their knowledge, this individual may accept they are dumb. Men brought up in preservationist social orders may have the conviction that ladies who work outside of the house are not in the same class as the individuals who don't work outside of the home. It takes a great deal of work to take a gander at yourself and recognize the convictions that are influencing your life in a negative way. Nonetheless, realizing your convictions will give you a sound reason for passionate opportunity. I do accept that it’s astute to manage the conviction frameworks before managing the recognizable proof and arrival of feelings. First of all!  · Other People, Places, and Things Cannot Change How You Feel The main individual who can change what you feel is you. Another relationship, another house, another vehicle, a new position, these things can immediately divert you from your emotions, however no other individual, no material belonging, no action can expel, discharge, or change how you feel. How regularly do you hear individuals make statements like â€Å"when I have enough cash, I won’t be apprehensive anymore†, just to see there never appears as enough cash to quit being apprehensive. Or then again â€Å"when I’m in a protected relationship I won’t feel forlorn any more†, and discovering they are still desolate paying little mind to their relationship. We have to comprehend that we take our emotions with us any place we go. Another dress, another house, a new position, none of these things change how we feel. Our emotions stay inside us until we discharge them.  · Emotions Are Not the Only Cause of Illness Feelings are not by any means the only aim of sickness. Little children and youngâ children get sick, and not generally due to their intense subject matters. There are numerous reasons for sickness including feelings, yet they are not the sole reason for ailment. The reasons for sickness to

Equality Rights: Feminism

Correspondence Rights: Feminism Correspondence Rights Feminism Equity a term related with reasonableness, union, and rights has been a significant objective for different hypothetical developments that have framed in Feminism. The discussion encompassing fairness has and keeps on being of worry at all various levels women's liberation emerged as a reaction to the disparities among people. The topic of fairness itself sets up a parameter of examination and evaluate that takes into account examination and theory. To contemplate balance, is to edify the faculties to investigate the potential outcomes of what is known, what should be done, and who or what is engaged with looking for balance it challenges the word just as the individuals confined inside it. Catharine MacKinnon states that â€Å"Feminism is the disclosure that ladies don't live in this world, that the individual possessing this domain is a man, a lot more a man on the off chance that he is white and wealthy† (367). In view of this, women's activist developments accentuate the significance of each women’s position in social and political spaces. Different women's activist developments can be utilized to accomplish fairness. Notwithstanding, every viewpoint gives an alternate commitment in getting such fairness. Women's activist speculations of the liberal, Marxist, radical, and postcolonial viewpoints all spread certain parts of imbalance while constraining in the affirmation of another. The coordination of these points of view will take into account a genuinely helpful balance for ladies. Liberal women's liberation is a position that contends for ladies to have equivalent rights to men and to accomplish singular independence. They propose a model of individual self-sufficiency by battling for the privilege of ladies to have instructive chances and to acquire a vocation that is outside of home life. This is a piece of their primary focal point of their make progress toward ladies to have similar rights that men hold â€Å"naturally† men being the sexual orientation of benefit and force (Whelehan 29). Liberal women's activists are keen on the legislative issues of law to keep up fairness among ladies and men. From this viewpoint, correspondence for ladies is feasible however because of the nature and power of its developments, liberal women's liberation is considered as a beginning stage for equivalent rights and opportunities ensured to every person. It adopts a more â€Å"soft† campaigning strategy to battle for the equivalent privileges of ladies to those of men as they attempt to cease from any immediate test to organizations that cause them to be inconsistent. They might want to change laws yet remain inside the limits of foundations as they end up being significant to numerous ladies. Imelda Whelehan brings up that the â€Å"liberal point of view on state mediation in people’s lives additionally demonstrated risky, since state support was urgent to numerous women’s lives, and any shrinkage of its administrations would likely imply that their expectations for everyday comforts deteriorated† (34). Thus, liberal women's activists were gotten between battling for women’s rights and communicating their exploitation that is because of their disparities in organic sex. In addition, social change is limited in such a case that the present liberal state was toppled, the male-predominant liberalistic the state of affairs would be disturbed and numerous administrations gave by the state (particularly benefits gave to ladies to improve their expectations for everyday comforts) will be in risk. Consolidating liberal idea and women's liberation gives numerous logical inconsistencies on the grounds that their convictions don't have any significant bearing similarly to both male and female because of the imperatives of the real world. In the event that guys and females are given equivalent rights (as trusted by liberal women's activists), there will be strains on both genders as far as sexual orientation jobs inside and outside of the economy just as an accentuation on the females natural life structures of conceiving an offspring. Subsequently, liberal feminism’s idea of correspondence is a perfect that is conflicting because of the real world, individual advantages, and ecological requirements, (for example, the state, training, and family needs). Realize this doesn't really demonstrate liberal woman's rights as an incapable way to deal with balance. Truth be told, liberal woman's rights is the most broadly known women's activist development in today’s society. The liberal women's activist development can be viewed as the premise and the beginning stage for the battle towards sexual orientation uniformity. Be that as it may, this methodology should be joined with different points of view for a progressively viable result. Another powerful way to deal with make progress toward sex correspondence is to break down the issue through the Marxian system. Marxist woman's rights underscores that private enterprise and male centric society are sorting out gadgets that upset the examination of having a general public that is equivalent between sexual orientations. They contend that class is a main consideration that makes the division among people. At the end of the day, the pecking order arrangement of class produces disparities by setting power in the hands of a couple while abusing others that don't have this benefit. Marxist woman's rights concentrates on women’s position in labor and in the industrialist framework women’s support in the home and in wage work. Heidi Hartmann states that â€Å"the issue in the family, the work market, economy, and society isn't just a division of work among people, yet a division that places men in a predominant, and ladies in a subordinate, position† (7). Subsequently, Marxist women's activists adopt on a progressive strategy to topple private enterprise so as to destroy male benefit [really ridiculously great clean cut statement]. They perceive that ladies are subjected as a class and that women’s unpaid work in the home should be recognized on the grounds that â€Å"women at home not just offer fundamental types of assistance for capital by repeating the work power, yet additionally make surplus incentive through that work† (Hartmann 8). Besides, Marxist women's liberation perceives the social and recorded setting of all women’s work in paid and unpaid work. By recognizing women’s interest in the public arena, women’s commitment won't be underestimated subsequently raising their sex status. Equity can accordingly be accomplished from an industrialist perspective. While the liberal methodology centers around sexual orientation uniformity in rights under the watchful eye of the courtroom, the Marxian point of view adopts on a free enterprise strategy reinforcing women’s status in the monetary framework. These two methodologies plan to battle for more force for mistreated ladies in any case, simultaneously, they need center around a significant wellspring of this abuse the hazardous male-predominant sex framework. Radical women's liberation is valuable in examining this issue as it centers around male controlled society as the wellspring of sexual orientation imbalance. This double sexual orientation framework supposedly is a social develop that fills in as the premise of sex imbalance. Radical women's activists contend that men’s benefit mistreats ladies however social organizations and social creations. Therefore, men’s predominance over ladies supposedly takes on a social chain of command that produces inconsistent force relations. They stress that social associations made male control, which has constrained upon society a kind of reasoning that is â€Å"malestream.† Moreover, brutality towards ladies and the generalization of women’s bodies have set ladies in a place of misuse and exploitation. Radical woman's rights begat the trademark â€Å"The individual is political† to stress that individual encounters brings out policy driven issues that should be tended to and recognized. They adopt on a progressive strategy in that social and political changes are fundamental so as to oust the basic structure of disparity among people. They contend that â€Å"individual female character and experience [is] the initial step to aggregate revolution† (Whelehan 36). Recognizing female personality separated from the auxiliary sex structure will permit the female sex to break free from â€Å"malestream† standards. As it were, the end of this sexual orientation framework will perhaps bring the two sexes into equity. Another women's activist development that intends to challenge existing social standards and builds is postcolonial women's liberation. This development centers around dismissing all essential idea that is referred to and utilized as truth. They contend that this reality is developed and made by the forces of those that are the colonizers (working class, white guys) who have control over the colonized. In addition, this fact turns out to be a piece of the all inclusive it is acknowledged to be valid with practically zero addressing. Subsequently, postcolonial women's activist reject universalizing standards since it minimizes those that are not part of the standard. Leela Gandhi contends that a â€Å"comprehensive destroying of pilgrim chains of importance and structures should be coordinated by a changed and innovative reconception of colonized society and culture† (82). Postcolonial women's activists stress that ladies are arranged in a â€Å"double colonization† in which they are persecuted as ladies and colonized individuals just as built as sexual articles. A transformation of the built male-prevailing society should occur patching up every social standard that normally set ladies as the subordinate. By destabilizing the colonization, goals on sexual orientation that are underestimated will be ousted allowing an open door for ladies to be recognized in the public eye. With an expanded degree of energy about women’s commitment, equity between the sexual orientations can be accomplished. With the one of a kind outlook of every point of view, imbalance issues in regards to various structures of society can be seen better. Every one of these points of view is powerful in their own particular manner as they all mean to bring uniformity between the sexual orientations. By consolidating the numerous viewpoints, equity can be accomplished somewhat. The issue of equity depends on people’s points of view and the social settings these individuals are situated. Regardless

Risk Assessment of One Tel Company †Free Samples for Students

Question: Examine about the Risk Assessment of One Tel Company. Answer: Intrdouction The title of this report is the hazard appraisal of One Tel Company. As the title recommend the report has recognized the different variables that have contributed towards the hazard level in the budget reports at the more significant level. Every single business in itself conveys the hazard. No business can run without the presumption of having the hazard in it. Hazard may comprise of any structure. It might be identified with the buys made by the organization as in subsequent to getting the installment the provider may not send the merchandise or might be identified with the deals made by the organization in the manner that the client may postpone the installment or most noticeably awful circumstance of not having the installment, etc. Along these lines the hazard is looked by each sort of business. The principal point of the report is evaluate and distinguish the variables that add to the high intrinsic hazard at both the level monetary revealing and the record balance. The subseq uent point is to recognize the region which shows that the going concern is at high, low or medium hazard extend. With these contemplations the report has been set up with primary three areas. In the main area the elements have been definite which has expanded the natural hazard at the money related announcing level and in the second segment the components have been point by point which has expanded the intrinsic hazard at the record balance level. In third area, factors influencing the going concern have been itemized. From that point the report has been wound up with the finish of in general discoveries and proposal consequently. Intrinsic Risk At Financial Reporting Level From the earliest starting point of this world, history has seen numerous conditions which portrays that the every single business faces hazard. The authentic occasion that underpins the above actuality is of Lehman Brothers. The organization has put more in the genuine area, monitoring the way that the part will be dropped down, because of which the 160 years of age organization is strongly required to record the insolvency application. In this manner, hazard is the necessary piece of the each sort of business and it will be thought about by the businesspeople. Simultaneously the reviewer of the organization is likewise required to consider the hazard in business all together arrangement his review in like manner and play out the review work in a productive way (Karen, 2014). Three types of dangers have been set somewhere near the bookkeeping and the inspecting principles relying on the nature, size and the kind of business inside which the organization is working. These are natural dangers, control dangers and discoveries (ASA 315, 2014). In the given contextual analysis of One Tel. Organization, the conversation has been accomplished for just the inborn dangers. Natural dangers is characterized as the opportunity of having the oversight or cancellation of any material truth from the budget reports of the organization because of the reasons which are absolutely out of the hands of the organization for example because of wild reasons. At the end of the day the natural hazard signifies that the likelihood of having the misquotes which is material because of wild factors. It connotes that the natural hazard will be available where there are factors which are crazy and not there where is the absence of control in the arrangement of the organization. The insp ector of the organization will assess this hazard with the utilization of his due expert consideration and expert abilities (Nosberger, 2015). This sort of hazard principally bring about because of the way that there have been some inalienable restrictions which is the piece of the matter of the organization and can't be constrained using any and all means. In the given case, following are the variables that have contributed at the money related revealing level with the expanded inborn hazard evaluation: Absence of Integrity of Management The administration of the organization will have uprightness and will pick up regard in the market inside which the organization is working. In the event that the administrations trustworthiness inside the market gets down then the notoriety of the organization in the market will likewise get drained (Leong, 2009). The absence of trustworthiness of the administration is affirmed when the evaluator option to contact others available is limited to perform honesty check. Along these lines, the absence of trustworthiness expands the degree of inborn hazard at the degree of money related detailing made by the examiner. The executives Experience Management experience assumes significant job in the compelling working of the organization. In the event that the group of the administration isn't experienced, at that point the organization will before long be in the circumstance of the disappointment (Cohen, Krishnamoorthy and Wright, 2007). In the given case the organization has the supervisory group which doesn't have the enough experience and have itself conceded that the supervisory crew has the restricted information and experience (Wielligh, 2015). The absence of information and the experience will prompt inappropriate planning of the monetary report. Additionally the administration of the organization is employing the new executives which will again show that there is the high pace of conservation in the top situations as the great and fair group will consistently oppose in fouling up and in this way will be viewed as the high unsafe region by the examiner (Monroe and Woodliff, 2013). In this way, alongside the above elements the reviewer will likewise consider the elements like weight on the executives with respect to poor incomes, misfortune and nature of the matter of the organization and elements which influencing the business wherein the organization is working for evaluating the innate hazard at the budgetary revealing level (Knechel, 2007). Intrinsic Risk Ataccount Balance Level The intrinsic hazard additionally presents in the record balance level with regards to how the record adjusts might be controlled by the organization and here the components are examined which delineates that there might be inborn elements which may add to the higher characteristic hazard. Stock Level-The stock assumes the significant job in making a decision about the liquidity of the organization from the essence of the accounting report of the organization. Keeping up the more significant level of stock delineates that the organization is having liquidity issue and the organization can't sell the item inside the hour of the working cycle. In the event that the organization keeps up the lower level of stock then there will again the danger of having the loss of clients. Accordingly, there are the high odds of stock to misfortune or misappropriation. (Mill operator, Cipriano and Ramsay, 2012). Irregular Transaction The surprising exchange has occurred on account of the offer capital of the organization. The offer capital of the organization has been significantly expanded from 355.60 million dollars in the time of 1999 to 1225.60 million dollar in the time of 2000. The expansion has been fundamentally invited by the organization through the issue of portions of the organization as opposed to the increment in benefit of the organization. Along these lines, it very well may be said that the organization can't produce the benefits of the organization and rather have financed the activities of the organization through the issues of the portions of the organization and gathering the sum from the investors of the organization (Shariff and Chan, 2008). The extensive increment so made have frightened the circumstance of the reviewer as to design the review likewise keeping in thought the intrinsic danger of having the other abnormal exchanges too in the budget summaries like incre ment in additional conventional things, increment in the deterioration, and so on. Evaluation Of Going Concern The rule of going concern has been given by the sound accounting standards and the organization needs to do the bookkeeping and need to set up the fiscal summaries as per the suspicion of the going concern. The presumption expresses that the organization will work in future and the budget summaries will be set up as such just (Blay and Geiger, 2013). Following are the components that have added to the high hazard influencing going worry as deciphered from the budget summaries of the organization: Sequential Loss Making for most recent two years The Company has been acquiring the misfortunes throughout the previous two years. In the time of 1999, the organization has brought about the loss of 68.70 million dollar and 282.10 million dollar in the time of 2000. In this manner the Net Profit proportion has been extensively diminished. The table subtleties the figuring: Year Net Profit/(Net Loss) Deals (Assumed) Net Profit Ratio/(Net Loss Ratio) 1999 (68.70) 1000 (6.80) 2000 (282.10) 3000 (9.50) Poor Cash Flows The Companys income articulation delineates that more money has been paid to the clients and workers of the organization and comparing less money has been gotten from the clients. The sum paid equivalents to 684.80 million dollar and the sum got equivalents to 510.90 million dollar. It shows that in the forthcoming years the organization will before long face the liquidation issue. Additionally toward the year's end, organization has demonstrated the net decline in real money and money likeness 6.6 million dollars. Further the organization has made overwhelming interest in the Property Plant and Equipment adding up to 613.10 million dollar however the advantages so expanded have not made the organization either to create the incomes or to produce the benefits. Aside from the above components there are factors too which shows that the zones of going concern are evaluated at significant level like unexpected increment in the expanding pace of Accounts Payable when contrasted with debt claims, compelling working of contenders, and so on. Specifics 1999 2000 Change (%) Records Payable 73.0 277.20 279.73 Records Receivable 72.0 218.40 203.33 End and Recommendation The organization One Tel is in the telecom business and has been developing from that point forward. The organization has not considered the sort of dangers that is available in th

Sales Manager Resume Examples, Template Complete Guide

Sales Manager Resume Examples, Template Complete Guide So, you chose to chase a career path in sales? Well, good for you! Not only does every company need good salespeople, but selling can be implemented in all aspects of life.When we present an idea, we need to sell it.When were convincing a friend to go see a certain movie with us, we need to sell that idea. When were applying for a job position, and the interviewer asks us questions about ourselves, we need to what? Thats right, we need to sell!Even though you might think of yourself as someone, who is an experienced salesman, getting a job can prove to be quite tricky. Every step needs to be done right in order for you to get that position.One of the first and most important steps in getting your dream job is writing an excellent resume and today, we are here to help you do exactly that.We will cover all the ins and outs of writing a resume for the position of a sales manager.Without further due, lets get to it!Sales Manager Resume Example Right Sales Manager Resume Sample Right Create your own resumeLEARN HOW TO SELL YOURSELF AS A SALES MANAGER IN PERSONAL INFO SECTIONEvery resume should begin with the personal info section where you give clear information about yourself as a candidate.The information you give here is pretty much very straightforward, and you may be thinking to yourself Why do I need to read a guide on how to write the personal info section? I know my own personal information very well.Well, even though this might seem obvious, trust us when we say that a lot of people get this part wrong. It happens a lot actually, that people fill out some of their information unprofessionally or in the wrong way and that costs them a job opportunity.So, to make sure you dont make the same mistake, we will go through some examples of the right and wrong way to fill out a certain part of the personal info section.Hopefully, by reading this part, you will be aware of those small mistakes you should be on the lookout for.Lets begin!Full NameYour name should definitely be the easiest field to fill out. Yet, some people still manage to complicate it. Dont put any funny nicknames that will make you seem unprofessional. Keep it simple and the recruiter will love it.Jane Felson RightJane 'sales wonder woman' Felson WrongProfessionIf your line of work is more concrete than just a sales manager, feel free to write it so.Recruiters appreciate precision. For example, if you specialize in digital, write that you are a digital sales manager in the professional field. If you did various jobs during your working experience, dont worry. Writing down that youre a sales manager still works.PhotoIf your picture isnt professional, dont expect a call for an interview. Pictures of you at a social event or you at a cooking class simply wont cut it when we talk about resume photos.Headshots are always the best and safest types of photos you should use in your resume. Just make sure that the quality is good. It doesnt have to be billboard quality; the rul e of no pixels applies here.Phone NumberIf you dont want to leave your phone number in your resume, your potential loss is huge.Keep in mind that, even though it is 2019 and the majority of us prefer digital channels of communication, there are still people who prefer the good old phone call.The interviewer might try to reach you that way, and if you dont answer, it will leave a very bad impression. So, our advice is that you write down a phone number you will check regularly. Dont say we didnt warn you!AddressYour address can be left out of the resume but bear in mind that some recruiters want to know how far away you live, in case you might need help with transportation to work.Also, they might need to relocate you, and they would like to know that in advance.E-Mail AddressThe chances are, you will receive further information about the selection process by e-mail, so make sure that you write down your actual address which you are going to check regularly.By regularly, we mean at l east once a day. Leaving an e-mail from a company unanswered will make you look very unprofessional in their eyes and will take a lot of work to make up for. Like with phone calls, dont say we didnt warn you!felsonjane56@gmail.com Rightjanewonderwoman56@gmail.com WrongSocial Media ProfilesWe always advise people to share their LinkedIn profile with their potential employer.The reason is simple think of LinkedIn as your broader resume. You would want for the recruiter to see everything you did in your working experience, wouldnt you? Well, they can see just that on your LinkedIn profile.Facebook and Instagram are optional, especially Instagram, since it is a very private social media platform where you can only post pictures and videos.Here is our recommendation for social media you should share in your resume if you have them:Your LinkedIn profileYour Facebook profileYour Skype IDIf you dont have a LinkedIn profile yet, seriously, make one. Trust us, it will come in handy.SUMMARY IS THE 2nd THING RECRUITERS LOOK IN   YOUR RESUME â€" WRITE IT AS A PRO!Try to be as concrete as possible in the summary section, while still leaving room for further explanation in the experience section. We know that this is a fine line, but its possible.Focus on pointing out your main achievements during your entire working experience. If you wish to do so, you can also mention your plans for the future and what exactly you are looking for.Lets look at the right and wrong example of writing the summary section.SummaryA top-ranked sales manager recognized for contributing to record sales figures. Successfully created more than 20 long-term partnerships with new accounts. I have a demonstrated history of working in different teams made of international members. Advanced cold-calling techniques, presentation and negotiation skills helped me drive more than 3,000,000$ revenue in my working experience. RightSummaryA top-ranked sales manager. Successfully created long-term partnershi ps with new accounts. I have a demonstrated history of working in different teams made of international members. Advanced cold-calling techniques, presentation and negotiation skills helped me do my job best way I can! WrongFrom these two examples, we see how the Right one has much more valuable information for the interviewer. He or she will have a greater understanding of what exactly you did and what youve accomplished by looking at the Right example.EXPERIENCE SECTION THAT WILL MAKE YOU GET ANY JOB YOU WANT!In the experience section, use the fields to write down your main responsibilities and achievements.Choose a couple of main ones and write them down in a couple of bullet points. Lets take a look at the right and wrong example again: Right WrongNotice how the wrong example lacks any real information, other than where you worked in the past and how much time you spent there. Also, the wrong example has some irrelevant information.If youre applying for the position of a sales manager and you have experience in that area, noting down that you were a bartender will just open up more questions and take up unnecessary space on the resume.Rather, always try to give concrete and concise information about what you did, what were your responsibilities, and how you achieved your goals. Always describe your work with both qualitative and quantitative information. Recruiters will notice that and keep you in mind for further selection.TIPS FOR WRITING THE EDUCATION PART THAT VERY FEW KNOWEven though formal education is losing its worth in the eyes of employers, you should still note down your highest degree.Its true that a lot of employers nowadays are looking for people who can do the job right rather than highly-educated people, some companies still prefer candidates who have a college degree in their resume. Right WrongIf we compare the right and the wrong example, we see that again, the wrong one lacks valuable information. Your GPA score should be mentioned if your grades were good.Also, every additional activity you did during your studies will demonstrate how hard-working and devoted you are.Avoid writing down unnecessary information, like your high school degree.The recruiter might ask you about that on the interview, but there really isnt any point in letting them know which high school you went to if you have a college degree. If you didnt go to college, then feel free to write down the highest degree you have.HOW TO WRITE ABOUT YOUR SKILLS IN A RESUMEThis section should show your best self! You need to split section into 3 different “types of skills”.One is particularly related to the job that you are applying to as a sales manager and the other 2 are related to languages you speak, and other related skills that might increase your chances.Sales manager skills are hard or soft sk ills you posses in the area of sales. Here you should write down every skill that helps you be a great sales manager!Other skills are hard and soft skills which help you fit in the company, in a team, or in areas outside of sales.The Language part is self-explanatory, but only put down the languages you know at least at a beginner level.That means dont overcrowd this section for the sake of painting a picture of yourself as a better candidate. Lets take a look at the right and wrong example and dissect them: Right WrongWe see that the wrong example is very un-organized and that only a couple of skills are mentioned.Weve said that we dont condone overcrowding this section, but you should still use the fields you have to point out all of the hard and soft skills youve obtained during your studies and your working experience.TIPS TRICKS THAT WILL MAKE YOUR RESUME A GOOD DEAL FOR RECRUITERSNow that weve covered every segment and youve seen examples of how a great resume looks, you are basically ready to create your own amazing resume!But before that, lets take a look at some advanced tips tricks you should apply when going for a sales manager job position:Include these main sales manager skills Sales team supervision, new account development, relationship building and maintaining, partnership upscaling, stakeholder management, complex negotiating, territory management, creating proposals, presenting, sales training, lead nurturing, closing strategiesInclude these main sales manager keywords Achieved, influenced, established, coached, expanded, improved, trained, collaborated, closedDescribe your experience with data/numbers Whenever you can, describe your experience with data instead of words. KPIs (Key Performance Indicators) youve measured can now be of great use to you! Instead of stating that you contributed to revenue growth, state that revenue increased by 7% because of your contribution!Keep it at the length of one page Remember that not everything should be in your resume, only the most important things considering the position youre applying for. Rely on your LinkedIn profile to provide the information you couldnt quite fit in the resume. Put yourself in the recruiters shoes, if you had to go through 300 resumes, wouldnt you want them all to be short and to the point?Use the same font If you are not a designer, dont try to become one by experimenting with your resume. You are not applying for a designer position, and neither is that company looking for one. Keep it simple, use one font and you will be good.If any sentence is too long, cut it or split it It can happen that you go into too much detail when trying to explain something in the best way possible. This is why when you review your resume, check if any part is too long. If it is, simply split it into more parts or cut out a part of it. Sometimes, less is more, and this rule is especially true for resumes.Make sure your resume doesnt have any typos But really, there isnt an excuse for not checking your grammar. If book writers can check their 300+ pages, you can check this one page that may determine your next job. Not to mention that there are free apps available which can check this for you in a matter of seconds.Be prepared to answer questions about your job switching If theres a history in your experience section of you moving around jobs, expect questions about this. This doesnt have to be bad. All you have to do is to be sincere. The chances are that that the reasons y ou left were valid, and by talking about them, you set clearer expectations about how you want to be treated and how you want your work-life to look like.CONCLUSIONYou might be a beginner at writing resumes and applying for jobs, and you might be an experienced candidate. Whatever the case may be, we wish you the best of luck in the search for an ideal opportunity for yourself!Hopefully, by reading this article, you have seen that writing a resume doesnt have to be a painful process and that everybody can do it.We hope that you learned something new and that the guidelines youve read here will help you land your next dream job. We believe in you, you got this! Create your own resume

Plug the answer back into the sentence

Im convinced that one of the top reasons people lose points unnecessarily on Fixing Sentences is that they neglect to actually plug their chosen answer back into the sentence and consider it in context. While in some cases an answer may be clearly better worded or more grammatically correct than all the others, in many other cases multiple answers may appear perfectly correct on their own. In such cases especially ones in which you are dealing with a large amount of underlined information you should take the extra time and double-check that your answer actually works in terms of syntax, clarity, and punctuation. It is crucial that you pay attention to the punctuation aspect, particularly to the existing (non-underlined) commas within a sentence. This is because the comma splice (two full sentences joined only by a comma) is among the two or three most common types of wrong answer choices, and it shows up constantly. Constantly. If youre facing a full sentence on one side a comma, you cant have a full sentence on the other side. It doesnt matter how good it sounds or how much sense it makes in context its always going to be wrong. For example: During the Renaissance, glass products made on the island of Murano could only be crafted according to traditional techniques, whereby they forbade artisans to leave and set up shop elsewhere. (A) whereby they forbade artisans to leave (B) as a result artisans were forbidden (C) artisans were thus forbidden (D) it being forbidden for artisans to leave (E) and so artisans were forbidden (A) and (D) are pretty clearly wrong, but (B), (C), and (E) all seem relatively plausible, right? Heres the problem, though: the non-underlined portion of the sentence contains full sentence + comma, meaning that another full sentence cannot follow the comma without creating a comma splice. If we plug these options into the sentence in turn, we get: (B) During the Renaissance, glass products made on the island of Murano could only be crafted according to traditional techniques, as a result artisans were forbidden to leave and set up shop elsewhere. Thats two sentences separated by a comma, so thats out. (C) During the Renaissance, glass products made on the island of Murano could only be crafted according to traditional techniques, artisans were thus forbidden to leave and set up shop elsewhere. Thats also two sentences separated by a comma, so its out too. It is very important to note that the second clause really is a full, grammatical stand-alone statement, even though it may not make logical sense outside of any context. (E) During the Renaissance, glass products made on the island of Murano could only be crafted according to traditional techniques, and so artisans were forbidden to leave and set up shop elsewhere. This answer correctly uses a FANBOYS conjunction to join the two sentences, thus eliminating the comma-splice problem.

Use Of Factual Primary Sources For Bullying And What I...

For many years bullying has seemed to become a norm for people from all backgrounds and lifestyles within society. The unique thing about bullying is that at times it may occur amongst people that are closest to the victims. Such as, family members, friends, co-workers, or from other known and sometimes unknown assailants. There is no definitive way to pinpoint what makes bullying occur or how it will affect an individual. Because everyone has different tolerance levels and may find alternate ways to cope with bullying whether negative or positive. The purpose of this expository paper is to use factual primary sources to identify how real life bullying experiences can affect a persons life, this is based on real life experiences. I will clarify how these sources are relevant to bullying and what I learned from it. In addition I will explain what valuable information I learned from my primary sources that I didn t from my secondary sources. There many people who have given there accou nt on bullying experiences. Some of their accounts are pretty disturbing and will make you wonder what makes an individual or group of people harass and bullying someone else. Is there really anything someone can say to justify these actions? no there isn t. What can be said is that bullying has become a social problem that public-figures now are resorting to using their social status and influence to bring attention to this controversial topic. Many of these public-figures tell talesShow MoreRelatedLife Of Pi Questions6295 Words   |  26 Pagessixteenth-century Kabbalist and the admirable three-toed sloth. In subsequent chapters, he explains the ways in which religions and zoos are both steeped in illusion. 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Whole Exome Network Analysis Identifies CXCR5-CXCL13 Signaling as a Key Driver in Breast Cancer - Free Essay Example

Sample details Pages: 8 Words: 2498 Downloads: 2 Date added: 2019/02/06 Category Medicine Essay Level High school Tags: Breast Cancer Essay Did you like this example? I am delighted to submit the concept paper with the title â€Å"Whole Exome Network Analysis Identifies CXCR5-CXCL13 Signaling as a Key Driver in Breast Cancer† for consideration under the NIH Research Fellowship Program, Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship. The primary aim of the Kirschstein-NRSA Individual Predoctoral Fellowship is to provide financial support for mentored research training, leading to a doctoral degree in the biomedical, behavioral, or clinical sciences. Don’t waste time! Our writers will create an original "Whole Exome Network Analysis Identifies CXCR5-CXCL13 Signaling as a Key Driver in Breast Cancer" essay for you Create order However, this fellowship program also strives to enhance the diversity of the scientific workforce in the United States by providing opportunities for academic institutions to identify and recruit students from diverse population groups. This fellowship program encourages diverse population groups to seek graduate degrees in health-related research. The long-term goal of the Kirschstein-NRSA Individual Predoctoral Fellowship program is to enhance the number of scientists from diverse population groups and prepare them for research careers in the biomedical, behavioral, and clinical sciences. I am a fourth-year graduate student at Morehouse School of Medicine (MSM), a historically Black College or University in the Atlanta University Center. The mission of MSM is to increase the health and well-being of individuals and communities with emphasis on people of color. This mission is primarily focused on underserved urban and rural populations in Georgia. MSM also seeks to increase the diversity of the health professional and scientific workforce. This mission shares a similar objective to that described in the mission of the Ruth L. Kirschstein NRSA Individual Predoctoral fellowship. I am obtaining a Ph.D. in Biomedical Science and a Master’s degree in Clinical Research (MSCR). The PhD/MSCR program has provided me with a strong foundation in research design, methods, and analytic techniques. My ability to conceptualize and think through research problems has also been enhanced through my participation in this dual degree program. I have gained experience conducting re search as well as presented my research findings as first author. The PhD/MSCR program has afforded me the opportunity to interact with members of the scientific community at scientific meetings and workshops. Moreover, the dual degree program has provided me with a versatile skill which I can utilize in the next stage of my research career. Overall, I believe the Ruth L. Kirschstein NRSA Individual Predoctoral fellowship will provide me with financial support that will take my graduate career to the next level. My dissertation committee consists of 3 experts in Oncology (James Lillard Jr. PhD, MBA, Shailesh Singh, PhD, and Sanjay Jain, MD), 1 expert in Toxicology (Danita Eatman), and 1 Biostatistician (Fengxia Yan, MD). Bioinformatics support will be provided by the bioinformatics core at Morehouse School of Medicine, The Georgia Institute of Technology, and Emory University. PURPOSE Breast cancer (BrCa) is the second leading cause of cancer related deaths in American women (American Cancer Society, 2018). Approximately, 1 in 8 (12%) women in the United States will develop invasive BrCa during her lifetime (American Cancer Society, 2018). In 2018, approximately 250,000 new cases of invasive BrCa will be diagnosed in women and of these women, approximately 40,500 will die from the disease, about 1 in 36 (3%) (American Cancer Society, 2018). More recently, incidence rates have been stable in Caucasian women, but have increased in African American women. This BrCa health disparity is most notably observed in Triple Negative Breast Cancer (TNBC). TNBC is characterized by a lack of molecular markers; estrogen receptor (ER), progesterone receptor (PR), and the human epidermal growth receptor 2 (HER-2). It accounts for 10-20% of all BrCas and is an aggressive disease with poor prognosis (Pierobon, 2013). TNBC incidence rates are higher in Caucasian women. However, the number of fatalities associated with TNBC is significantly higher in African American women, than compared to other ethnic groups. If no major changes in prevention or treatment occur, the number of lives lost to TNBC will continue to rise. More recently, rapid increases in early stage, BrCa incidence have been reported in pre-menopausal women less than 45 years of age. Additionally, many of these young, early stage breast cancer patients are of ethnic descent. The mechanisms responsible for early stage BrCa in young women of ethnic descent remains unknown. Furthermore, it remains controversial whether early breast cancer has unique tumor biology, which may be highly influenced by race. Despite new developments in early detection and treatments, approximately 5% of women diagnosed with BrCa in the United States will develop metastatic disease at the time of first presentation (EBCTCG, 2005). Additionally, another 30% of women with early-stage, non-metastatic BrCa at diagnosis, will develop distant metastatic disease that is not curable (EBCTCG, 2005). Additional predictive markers and new drug targets are needed to prolong survival and improve the quality of life for BrCa patients. It is essential to understand the mole cules and mechanisms responsible for the aggressive phenotype of breast cancer to develop new, more effective drug targets for the disease. Currently, there are no specific targeted therapies for TNBC due to the lack of ER, PR, and HER-2 markers. Current chemotherapy consists of a combination of drugs including paclitaxel (TAX), doxorubicin (DOX), and cyclophosphamide (CTX)]. TAX is a taxane, which disrupts microtubule function, inhibiting the process of cell division (Singh, 2014). It is more commonly prescribed than docetaxel, another member of the taxane family, due to its tolerable toxicity and is noted as first line therapy in metastatic disease (Erba, 2010). DOX is an anthracyclin, which inhibits DNA and RNA synthesis by intercalating between base pairs of a DNA/RNA strand (El Haibi, 2011). In an effort to combat the acute toxicity associated with DOX, it is often prescribed in combination with TAX (Eralp, 2004). CTX is an alkylating agent, which adds alkyl groups to DNA, which in turn interferes with DNA replication by forming DNA crosslinks (Singh, 2014). It is conditionally prescribed in combination with TAX and DOX, based on disease progression. The ability of CTX to induce the death of certain T regulatory cells contributes to its efficacy. However, this combination therapy produces undesirable side effects. A response rate for a treatment regimen of TAX + DOX + CTX in TNBC patients is a mere 12% for a single agent and can widely vary, 27-65%, for use of multiple agents (Singh, 2014). Patients eventually relapse as a result of chemoresistance and metastasis, ultimately succumbing to this disease. This brings attention to the cells potentially responsible for drug resistance in the tumor microenvironment. The tumor microenvironment is composed of tumor cells as well as various types of stromal cells, such as fibroblasts and endothelial cells. Several types of inflammatory cells including neutrophils, macrophages, and lymphocytes are recruited to breast tumors and play either a positive or negative role in cancer progression. The infiltration of inflammatory cells is regulated by a variety of biologically active molecules in the tumor microenvironment. Chemokines play a significant role in this process (Singh, 2011). Chemokines are 8-10 kilo Dalton (kD) chemotactic cytokines involved in cell trafficking events and normal homeostasis. They are grouped into 4 major subfamilies (C, CC, CXC, and CX3C) based on the pattern of the two NH2-terminal cysteine residues. The extended N-terminus functions to recognize, bind, and activate the receptor. BrCa cells express Chemokine Receptor 5 (CXCR5). Chemokine Ligand 13 (CXCL13) is the sole ligand for CXCR5, which plays a role in cancer progression (Singh, 2009; Singh, 2009; Singh 2011). Our laboratory was the first to show that CXR5-CXCL13 signaling mediates prostate cancer metastasis and progression i.e., growth, migration, and invasion, and survival (El Haibi, 2010-2012). We also demonstrated that CXCR5-CXCL13 signaling induces cancer progression signaling pathways: PI3K, AKT, ERK, and Jun (El Haibi, 2010-2011). However, the mechanisms, by which, CXCL13-CXCR5 signaling promotes breast cancer is unknown. Panse et al revealed CXCR5 and CXCL13 are overexpressed in BrCa tissue (Panse, 2008). This study also showed elevated serum levels of CXCL13 in BrCa patients with metastatic disease, then compared to controls and disease-free patients. Additionally, a recent study provided evidence that co-expression of CXCR5 and CXCL13 showed a significant correlation with lymph node metastasis and independently, CXCL13 had EMT-inducing potential (El Haibi, 2010). Taken together, these findings suggest the CXCR5-CXCL13 signaling axis contr ibutes to the aggressive phenotype of breast cancer (BrCa). The central research questions of this project focus on determining the mechanisms and molecules responsible for differences in tumor biology of young BrCa patients and how these mechanisms and molecules contribute to poor BrCa prognosis. The purpose of this study is to characterize the molecular phenotype of (BrCa) in the context of Chemokine Receptor 5 (CXCR5), Chemokine Ligand 13 (CXCL13), and associated gene expression. This study is novel as uses a bioinformatic approach and gene enrichment analyses to identify the specific molecules and mechanisms responsible for the aggressive phenotype of BrCa, especially in young and early stage BrCa patients. These two unique populations account for a high proportion of BrCa cases and are also associated with unfavorable prognosis. The results from this study have the potential to benefit young and early stage BrCa patients as it will serve as a new predictive factor and therapeutic target for young and early stage BrCa patients. PROJECT DESCRIPTION Breast cancer (BrCa) is the most frequently diagnosed cancer and the second leading cause of cancer-related death among women worldwide (American Cancer Society, 2018). Several targeted and adjuvant therapies exist for estrogen receptor (ER) and human epidermal receptor-2 (HER-2) positive breast cancers. Currently there are no targeted therapies for Triple Negative Breast Cancer (TNBC), which lacks the three main receptors used to characterize breast cancer subtypes; estrogen receptor (ER), progesterone receptor (PR), and human epidermal receptor-2 (HER-2). Despite new developments in early detection and treatments, approximately 5% of women diagnosed with BrCa in the US will develop metastatic disease at the time of first presentation (EBCTCG, 2005). Additionally, another 30% of women with early-stage, non-metastatic BrCa at diagnosis will develop distant metastatic disease that is not curable (EBCTCG, 2005). Additional predictive markers and new drug targets are needed to prolong s urvival and improve the quality of life for BrCa patients. Panse et al revealed levels of CXCR5 and CXCL13 are elevated in serum and overexpressed by tumor tissue in metastatic BrCa patients. The long-term goal of this study is to further characterize the molecular phenotype of BrCa in the context of CXCR5, CXCL13, and associated gene expression. We hypothesize the CXCR5-CXCL13 signaling axis contributes to the aggressive phenotype of BrCa. A bioinformatic approach will be used to aid in characterizing this new drug target for BrCa. Our patient cohort (1,049 female patients of Caucasian, African American, Latin American, and Asian/Pacific Island descent, age 35-82, diagnosed with ductal and lobular carcinoma ) will be obtained from The Cancer Genome Atlas (TCGA). All patients within the cohort have verification of informed consent and IRB approval. Differential Expression Sequencing (DESeq) analysis will be performed to identify genes differentially expressed among primary tumor and matched normal, solid tissue groups. Weighted Gene Network Co-expression (WGCNA) analysis will be performed to identify modules of co-expressed which will be correlated to factors influencing BrCa prognosis, such as age at diagnosis, TNM staging, race, menopausal status, breast cancer subtype, and survival time. Finally, canonical pathway, upstream regulator, and gene interaction analysis will be performed using Ingenuity Pathway Analysis. Our findings suggest CXCR5, CXCL13, and associated genes driving tertiary lymphoid structure formation, is present in BrCa, may serve as a predictive factor, and a new therapeutic target. GOALS AND OBJECTIVES The long-term goal of this study is to further characterize the molecular phenotype of BrCa in the context of CXCR5, CXCL13, and associated gene expression. We hypothesize the CXCR5-CXCL13 signaling axis contributes to the aggressive phenotype of BrCa. The objective of this study is to identify the molecules that contribute to the aggressive phenotype of BrCa in silico. METHODOLOGY Data Collection and Normalization The data used in this study will be obtained from The Cancer Genome Atlas (TCGA). Clinical and RNA-seq data, for a total of 1049 female patients of Caucasian, African American, Latin American, and Asian/Pacific Island descent, age 35-82, diagnosed with ductal and lobular breast cancer carcinomas will be obtained. All patients within the cohort have verification of informed consent and IRB approval. Detecting Low counts, Batch Effect Correction, and Removal of Outliers A minor limitation of RNA-Seq analysis is the presence of missing expression counts, which alters the distribution of the population. Due to this limitation, normalized counts for all 1,049 patients with 26,000 protein coding genes will be log2 transformed (expression value+1) to create a standard normal distribution. Genes possessing greater than 50% zero counts will be removed to prevent a skewed distribution and remaining genes will be filtered by a standard deviation of 1. We predict that between 5,000-8,000 protein coding genes will be analyzed for batch (center) effect. Using ComBat algorithm, batch effect correction will be applied to detect variance from a total of 52 sequencing centers that contributed to the TCGA BRCA dataset. ComBat, an Empirical Bayes method in the Bioconductor SVA package, will be used to remove all outliers. Detection of Differentially Expressed Genes among Primary Tumor and Matched Normal Samples using DESeq Differential Expression Sequencing (DESeq) is a free software package in R that detects genes that are differentially expressed between two groups. In this study, we will detect genes that are differentially expressed between 113 primary tumor and 113 matched normal samples. Normalized counts for approximately 26,000 genes will be used to determine differential expression. Identification of modules associated with different stages of breast cancer primary tumors using WGCNA Between 5,000 and 8,000 genes will be entered into Weighted Gene Co-Expression Analysis (WGCNA) software. WGCNA is a free software package in R that extracts information on single genes from large scale gene expression profiles, across all patient samples, and uses this information to construct gene network modules of co-expressed genes. These co-expressed genes will be built on a manual threshold power of 6. Modules containing co-expressed genes have the potential to be associated with specific clinical traits. Association is based on a scale of 0-1 with an alpha of 0.05. Network calculation will allow for the identification of a module(s) of genes highly co-expressed with Chemokine Receptor 5 (CXCR5) and Chemokine Ligand 13 (CXCL13) and strongly correlated with clinical traits, such as age at diagnosis, TNM staging, race, menopausal status, breast cancer subtype, and survival time. Functional Enrichment analysis of genes within each module using IPA Following WGCNA, a network module(s) will be identified for functional enrichment containing genes co-expressed with CXCR5 and CXCL13. Ingenuity Pathway analysis (IPA) will be used to elucidate the biological roles of genes inside modules of co-expressed genes. Often modules contain co-expressed genes that contain co-regulated genes, with similar biological functions. These modules of co-expressed genes regulate epigenetic features downstream of particular transcription factors. Genes with high connectivity will be pooled together and IPA will be used to perform an analysis that shows the canonical pathway of selected module hubs. Upstream Regulator Analysis using IPA The Upstream Regulator analysis feature in IPA will be used to identify the biological function of significantly associated gene co-expression module(s) to BrCa stage. Co-expressed genes in this module will most likely be regulated by the same or similar upstream regulators, including transcription factors. We will identify the upstream transcriptional regulators in each module with a p-value of overlap

Car Repair For The Do-It Yourselfer Essay - 967 Words

Car Repair For The Do-It Yourselfer For most people driving a vehicle is a normal and every day process. On any given day driving in city or town traffic one can experience a number of noises by either their own of somebody else’s vehicle. Car repair can be very expensive, and lately, do-it-yourself projects are very popular. In today’s Internet world, the driver has an option to explore the World Wide Web for information on symptoms, problems, and, depending on the service, the repair procedure. This paper will concentrate on two web sites. The fundamental difference between the two is how much one advertises, and how the other sets the viewer in the right direction. The better of the web sites, in my opinion, is the one†¦show more content†¦A big complaint of many do-it-yourselfers is that the author or mechanic replicating the procedure has the nicest tools, and shop to work out of. This is not true of the articles I saw. The authors of the articles I researched made it a point to use readily made available equipment. An example of this is, using the vehicles jack that it came with instead of a floor jack. There are many links to other articles I found just as informative. The one that sticks to mind is from the magazine â€Å"Popular Mechanics†, titled the â€Å"The Saturday Mechanic†. The biggest advantage to this site is that there is also a link specifically used so viewers of the site can link informative sites too 10W40, and another use d for people to post stories and experiences with their cars. Most of the information here is from hundreds of sources on the Web. Also useful is the search engine on the top left corner. I think of this site as a directory to automotive information. The second web site is http://autorepair.about.com/. This web site seemed very commercial. The curator of the site was Vincent Ciulla. He is most likely a former mechanic, now an author of fix-it manuals. 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A Midsummer Nights Dream by William Shakespeare - 854 Words

A Midsummer Night’s Dream â€Å"Lord, what fools these mortals be (Shakespeare, 1546)!† In the beginning of this play, Hermia refuses her fathers demands to marry Demetrius because she loves Lysander. Her disobedience enrages her father so he presents Theseus with his dilemma, which does not work as well as he had hoped (Gianakaris). Hermia is presented with two alternative options, but neither suits her well. She runs off into the woods with Lysander to get married and from this, a chain of events arises. To make matters even more complicated, Puck is sent out to get the juice of a flower that, when poured in eyelids while asleep, makes people fall in love with the first creature they see. Situations arise from this love juice, and the plot thickens. In this play, Shakespeare creates a social commentary through the use of the themes of love, magic, dreams, and art and culture. â€Å"The course of true love never did run smooth (Shakespeare, 1516).† In this quote from the play, Lysander perfectly sums up one of the most important themes this play has presented to us, the hardships of love. Although a great deal of conflict arises from the romantic entities this play bestows upon us, it is not precisely a tale of love. It isolates the audience from the characters emotions in order to mock the suffering and ailments love presents to those infatuated in it. The cheerful and carefree tone this play has from the very beginning, makes it easy to enjoy the comedic nature of it withoutShow MoreRelatedA Midsummer Nights Dream by William Shakespeare1011 Words   |  4 Pages The play, A Midsummer Nights Dream, by William Shakespeare, demonstrates the difficulties of human love. 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Phonics Lesson Plan Free Essays

Title of Your Lesson| Digraph Picture Hunt| Grade Level| 4th| Subject| Phonics- Digraphs| Summary and Rationale (Connections to Big Goal/Unit)| Students will be working with digraphs. TTW will students what sounds /ph/, /th/, and /sh/ make as a reminder and then asked to give examples. The students will then be given poster board split into three categories for each of the three digraphs and will be working in groups of three to find words and pictures in magazines that fit into the three categories. We will write a custom essay sample on Phonics Lesson Plan or any similar topic only for you Order Now At the end of the activity, the students will present their findings as a summary and a test to make sure the activity was completed correctly. The goal of this activity will be for students to be able to recognize digraphs through pictures as words. Students will demonstrate understanding by responding to questions on whiteboards that they will hold up when questions are asked. | Classroom Scenario (small group, whole class, self-contained, resource, gen. ed. , spec. ed. nclusion)| This activity will be done with the entire class of fifteen, but students will be broken up into five groups of three. | PRETEACHING TASKS/PLANNING| | Common Core State Standards (CCSS)| 4. RF. 3Know and apply grade-level phonics and word analysis skills in decoding words. a. Use combined knowledge of all letter-sound correspondences, syllabication patterns, and morphology (e. g. , roots and affixes) to read accurately unfamiliar multisyllabic words in context and out of context. Objectives (One to two at most. TSW or TSWBAT†¦)(What will your students be able to do? What will students know by the end of this lesson? )| Students will be able to recognize /ph/, /th/, and /sh/ sounds through pictures and words in magazines allowing for easier recognition in real-life| Evaluation/Assessment (Is your assessment intimately aligned to your lesson’s objectives and standards? How will you know whether your students have made progress toward the objective? How and when will you assess mastery? Describe the task, the criteria/rubric, worksheet, check sheet, and goal for mastery. )| Students will be working together to find pictures and words in magazines that correspond to the digraphs we are concentrating on. When the students present their boards, the teacher will know whether or not they have understood what the sounds sound like and if they were able to identify them through pictures and words found in magazines. | Materials Needed (Graphic organizers, specific books, readers, word wall, sound counters, SMARTBoard, etc. )| Whiteboard, magazines, scissors, poster paper, glue| Accommodations/Modifications to be provided/Explicit Differentiated Instructional Strategies| * One-on-one time with teacher will be available for students struggling with the sounds * For differentiated instruction, TTW provide pictures of words and the student will sort them into categories based on their digraph * Another differentiated instruction activity will allow students to write lists of w ords in columns that are appropriate for certain digraphs and sound letter relationships. INSTRUCTIONAL PLAN PRELESSSON SUMMARY (WRITTEN REFLECTION)| SEE ATTACHED RESPONSE BELOW. | TEACHING PROCEDURES| | Building Background (Opener/Hook/Anticipatory Set) (How does this lesson connect to previous lessons/objectives taught? What visuals, video, or text reminders will you use? How you will excite students about the learning that will take place? How will you engage students in the language of the lesson’s objective(s)? Explain. )| When they break of into groups students will be excited that they get to work with their friends to go on an â€Å"in-class scavenger hunt†. TTW let the students know that they will be going on a scavenger hunt to find the sounds that have been written on the whiteboard. The word â€Å"digraph† will be introduced and gone over for students who do not remember it. To help the students remember the function of the digraph, the teacher will ask them to give me a few examples of words with the /ph/, /th/, and /sh/ sounds in them before beginning the activity. | Introduction of New Material (What 3 – 5 key points do you want to emphasize? How/what will you model for students? How will you ensure that students actively take in information presented? )| – Emphasize the specific digraphs previously mentioned – Show students that pairs of letters come together to make sounds in forming words – Allow students the opportunity to choose one word they found a picture for and spell it on the board for the other students to see the digraph pattern and picture they found| Guided Practice/Small Group Lesson Activities (This is where you practice your objective with students. How will you ensure that all students have multiple opportunities to practice? How will you scaffold practice exercise from easy to difficult? How will you monitor and correct student performance? )| The teacher will be walking around from group to group to check for group and individual understanding. TTW will look at the words they have found so far and make sure they are appropriate for the activity. If words are not matching the digraphs being used, TTW will explain why and help them find words that will work. Each group will be presenting so no student will be left out of the process. This exercise itself is self-contained so students will be doing as much as they can with out the help of a teacher. | Independent Practice (This is where you specifically evidence your objective’s goal (s) with the same activity but different items/prompts for individual assessment. How will the students apply the new knowledge they have learned? )| Each student will have pictures that TTW will provide to sort into piles based on their digraph. TTW will walk around and check the piles. To be able to check for entire class understanding, students will respond to activity related questions on whiteboards. | Lesson Closure (How will students summarize what they learned? How will students be asked to state or show the significance of what they have learned? How will you provide all students with opportunities to demonstrate mastery, or progress toward mastery of the objective? How will you specifically review your lesson’s objectives? * TTW will review the digraphs we have focused onTo summarize what we have learned, TTW will say a word and ask for a thumbs up or a thumbs down based on the word the teacher provided and whether it has a digraph sound or not| Extensions (How might you provide opportunities for extension? )| The teacher could make a class bulletin board with a bubble surrounding the three digraphs that we are focusing on. Students can find pictures at home that have those sounds and cut them out and bring t hem in to add to our class bulletin board. Bloom’s Taxonomy Levels Achieved in the Lesson. Please justify. (Found in your Instructional Plans Folders 1 2)| Remember, Recognizing, Recalling- Students will be working from long-term memory to retrieve knowledge from past lessons to complete this activity Understanding- Students will know which category to put their words and pictures into on their poster board by sorting their words and pictures by digraph Applying- The students will be taking knowledge they learned in one format and applying it to a new and different activity| How to cite Phonics Lesson Plan, Essay examples

Phonics Lesson Plan Free Essays

Title of Your Lesson| Digraph Picture Hunt| Grade Level| 4th| Subject| Phonics- Digraphs| Summary and Rationale (Connections to Big Goal/Unit)| Students will be working with digraphs. TTW will students what sounds /ph/, /th/, and /sh/ make as a reminder and then asked to give examples. The students will then be given poster board split into three categories for each of the three digraphs and will be working in groups of three to find words and pictures in magazines that fit into the three categories. We will write a custom essay sample on Phonics Lesson Plan or any similar topic only for you Order Now At the end of the activity, the students will present their findings as a summary and a test to make sure the activity was completed correctly. The goal of this activity will be for students to be able to recognize digraphs through pictures as words. Students will demonstrate understanding by responding to questions on whiteboards that they will hold up when questions are asked. | Classroom Scenario (small group, whole class, self-contained, resource, gen. ed. , spec. ed. nclusion)| This activity will be done with the entire class of fifteen, but students will be broken up into five groups of three. | PRETEACHING TASKS/PLANNING| | Common Core State Standards (CCSS)| 4. RF. 3Know and apply grade-level phonics and word analysis skills in decoding words. a. Use combined knowledge of all letter-sound correspondences, syllabication patterns, and morphology (e. g. , roots and affixes) to read accurately unfamiliar multisyllabic words in context and out of context. Objectives (One to two at most. TSW or TSWBAT†¦)(What will your students be able to do? What will students know by the end of this lesson? )| Students will be able to recognize /ph/, /th/, and /sh/ sounds through pictures and words in magazines allowing for easier recognition in real-life| Evaluation/Assessment (Is your assessment intimately aligned to your lesson’s objectives and standards? How will you know whether your students have made progress toward the objective? How and when will you assess mastery? Describe the task, the criteria/rubric, worksheet, check sheet, and goal for mastery. )| Students will be working together to find pictures and words in magazines that correspond to the digraphs we are concentrating on. When the students present their boards, the teacher will know whether or not they have understood what the sounds sound like and if they were able to identify them through pictures and words found in magazines. | Materials Needed (Graphic organizers, specific books, readers, word wall, sound counters, SMARTBoard, etc. )| Whiteboard, magazines, scissors, poster paper, glue| Accommodations/Modifications to be provided/Explicit Differentiated Instructional Strategies| * One-on-one time with teacher will be available for students struggling with the sounds * For differentiated instruction, TTW provide pictures of words and the student will sort them into categories based on their digraph * Another differentiated instruction activity will allow students to write lists of w ords in columns that are appropriate for certain digraphs and sound letter relationships. INSTRUCTIONAL PLAN PRELESSSON SUMMARY (WRITTEN REFLECTION)| SEE ATTACHED RESPONSE BELOW. | TEACHING PROCEDURES| | Building Background (Opener/Hook/Anticipatory Set) (How does this lesson connect to previous lessons/objectives taught? What visuals, video, or text reminders will you use? How you will excite students about the learning that will take place? How will you engage students in the language of the lesson’s objective(s)? Explain. )| When they break of into groups students will be excited that they get to work with their friends to go on an â€Å"in-class scavenger hunt†. TTW let the students know that they will be going on a scavenger hunt to find the sounds that have been written on the whiteboard. The word â€Å"digraph† will be introduced and gone over for students who do not remember it. To help the students remember the function of the digraph, the teacher will ask them to give me a few examples of words with the /ph/, /th/, and /sh/ sounds in them before beginning the activity. | Introduction of New Material (What 3 – 5 key points do you want to emphasize? How/what will you model for students? How will you ensure that students actively take in information presented? )| – Emphasize the specific digraphs previously mentioned – Show students that pairs of letters come together to make sounds in forming words – Allow students the opportunity to choose one word they found a picture for and spell it on the board for the other students to see the digraph pattern and picture they found| Guided Practice/Small Group Lesson Activities (This is where you practice your objective with students. How will you ensure that all students have multiple opportunities to practice? How will you scaffold practice exercise from easy to difficult? How will you monitor and correct student performance? )| The teacher will be walking around from group to group to check for group and individual understanding. TTW will look at the words they have found so far and make sure they are appropriate for the activity. If words are not matching the digraphs being used, TTW will explain why and help them find words that will work. Each group will be presenting so no student will be left out of the process. This exercise itself is self-contained so students will be doing as much as they can with out the help of a teacher. | Independent Practice (This is where you specifically evidence your objective’s goal (s) with the same activity but different items/prompts for individual assessment. How will the students apply the new knowledge they have learned? )| Each student will have pictures that TTW will provide to sort into piles based on their digraph. TTW will walk around and check the piles. To be able to check for entire class understanding, students will respond to activity related questions on whiteboards. | Lesson Closure (How will students summarize what they learned? How will students be asked to state or show the significance of what they have learned? How will you provide all students with opportunities to demonstrate mastery, or progress toward mastery of the objective? How will you specifically review your lesson’s objectives? * TTW will review the digraphs we have focused onTo summarize what we have learned, TTW will say a word and ask for a thumbs up or a thumbs down based on the word the teacher provided and whether it has a digraph sound or not| Extensions (How might you provide opportunities for extension? )| The teacher could make a class bulletin board with a bubble surrounding the three digraphs that we are focusing on. Students can find pictures at home that have those sounds and cut them out and bring t hem in to add to our class bulletin board. Bloom’s Taxonomy Levels Achieved in the Lesson. Please justify. (Found in your Instructional Plans Folders 1 2)| Remember, Recognizing, Recalling- Students will be working from long-term memory to retrieve knowledge from past lessons to complete this activity Understanding- Students will know which category to put their words and pictures into on their poster board by sorting their words and pictures by digraph Applying- The students will be taking knowledge they learned in one format and applying it to a new and different activity| How to cite Phonics Lesson Plan, Essay examples