Limiting the Extent of Party Discipline in Canada Essay Example for Free

Limiting the Extent of Party Discipline in Canada Essay Party solidarity and cohesion have always been an integral part of the Westminster Parliamentry system. The leaders of the political parties of the Canadian House of Commons , with the assistance of whips, very strongly discipline their party members to vote on issues as a single entity, especially in plenary sessions (Olson, 2003). Although, some degree of party discipline is essential for any political party to maintain their power as they require the confidence of the majority of the legislative branch of the government, this practice does not really reflect a democracy. This paper argues that implememnting a large extent of party discipline undermines the spirit of democracy as the politicians become more concerned with appeasing their party leaders for their personal benefits, instead of truly representing the desires and demands of the citizens of their respective constituencies. As mentioned previously, it is argued that strict party discipline is necessary to ensure that the current governnig party maintains its power since a vote of non confidence in the House of Commons can ultimately lead to federal re-election, or re-appointment of the prime minister. However, as Kilgour et al. rgue in Crosscurrents: Contemporaty Political Issues (2013: 205), enforcing strict cohesion strategies to ensure party unity leads to members of Parliament to become extreamly passive as they no longer think for themselves, but merely conform to the demands of their party leaders. Their opinions and thoughts are constrsained by a fear of a loss of majority in the House Of Commons. It is very crucial for any political party to value and respect the opinions of its members to assess a situation more closely and obtain diverse opinions. However, strong party discipline stifles the values and opinions of individual members of party. Consequently, this diversity of imagination is replaced by a single unit of party that reflects a single, rigid opinion on most issues. This devalues the sense of liberty and freedom that is cherished by democracy. Often times, it is observed that the members of a party vote in a similar fashion, not just to ensure a majority confidence motion, but also to derive personal gains. If a member of parliament wishes to advance their political career and gain quicker promotions, he or she muct act according to the command of their party leaders (Kam, 2006). Expression of dissent from the MPs can have dire consequences for their career. They can be warned about the lack of financial support, or even be ultimately expelled from the party caucus. Kam (2006) also suggested that the promotion of ministers is greatly manipulated by the prime minister to ensure maximum conformation to the partys position. Sometimes, certain ministers of parliament are deliberately brought into the cabinet as it is too dangerous to leave them as a backbencher (a member of House of Commons) where they can openly challenge and vote against the position of the leader of the political party. This suggests that the deliberate promotion, or demotion, ministers of parliament is not due to their, merits or demerits, but is rather strategically devised to overall benefit the party. In addition, the vote of the members of the House of Commons not only does not represent the opinions of individual ministers, but also it not a representation of a members unyielding and unconditional loyalty to his or her party. Rather, it is a conscious decision to vote according to the wishes of the party leader to maintain the imge of conformity and ensure personal gains and benefits for the members of parliament, which would reward in the form of more opportunities to ascend the political ladder and make personal and professional gains that do not particularly benefit the citizens of the consituency that elected the member of parliament. It is unquestionable that voting in the Canadian House of Common is extremely disciplined and very highly regulated by emloying various methods. The study of the patterns of recorded votes shows that majority of votes show almost no dissent from the party members. Also, rejection of major government motions due to dissent of the members of the House of Commons is extremely rare (Malloy, 2003). Canada operates on a system of majoritarian parliamentary government. Cohesion of political parties is very essential to maintain a majority rule by ensuring that vote of non confidence is not ever issued (Kam, 2001). Due to this constant threat of the possibility of loss of majority and formation of a coalition, political parties are very strongly disciplined by their leaders. A coalition governmet is not necessarily always detremental. It can help to foster more cooperation in different political parties and compel the members of a party to consider the opinions and views that are different from the ideology shared by their party. It also provides an opportunity for a greater debate and consideration before arriving at a common decision. Maintaining strong party discipline just to eliminate the possibility of the formation of a coalitions limits the possibilities for political experimentation and possible positive growth. The change is not just welcomed, but also deliberately resisted using the traditional practice of oppressive party discipline. The members of parliament are elected by, and are required to respresent the citizens of their respective constituencies. The common vision shared by their party and party leader may or may not reflect the wishes of the citizens. The first and foremost duty of an MP is to cater to the needs and the demands of the citizens who democratically elected him or her. The loyalty to ones party should be a secondary priority. However, as observed, most times, this is not the case. This severely debilitates the sole purpose of a democratic government which demands the citizens voice and opinions to be heard above all others. Although some degree of party discipline may be required to control and maintain cohesion within the House of Commons to propose policies and arrive at a firm decision, it does not really encompass democratic ideas. Party discipline compells the members of a party to not pay heed to the needs of the citizens, but to blindly follow the demands made by their party leaders. This practice is also morally questionable as the political success of ministers of parliament is largely based on their loyalty to the partys alues, even if they contradict his/ her personal opinions. Instead of being constantly threatened by the possiblity of losing the confidence of the majority of the House of Commons, fundamental changes need to be made to change the Westmister Parliamentry structure to alter, if not eliminate, this system that makes it almost mandatory for the parties to implement rigid party discipline. Limiting the extent of the party discipline would help to make the Canadian government more democratic by accomodating more diverse ideas and opinions.

Economic Policy and The Global Environment

Economic Policy and The Global Environment 1 Introduction SMEs are seen as one of the critical handmaidens to huge relationship like change into one of their suppliers and sub-foremen to them. Hence, SMEs are key in the economy as giving a simple work business, structure gatherings of progress by presenting specific changes in the affiliations and close by SMEs utilizing high advancement based and give an adaptable and open to client. 1.1 Characteristic of SMEs Attributes of SMEs are dead set by factors like size of association or free proprietorship: 1.1.1 Impact of Age to the Business Study revelations help considered age of a relationship as a variable that may affect firm survival and improvement and/or definitive decline and passing the commitment of inventiveness that makes new SMEs face an a greater number of genuine threat of survival than more settled firms is that new firms dont have the experience, access, associations, reputation or the validness of the more settled firms, provoking limited access to external resources. 1.1.2 Impact of Location to the Business Geographic area has its suggestions for access to business sectors and different assets like finance, talented work, subcontractors, base, appropriation and transport logistics and other 10 offices. SME achievement additionally relies on upon neighborhood appearance and proceeded with or kept up future business operation in that area 1.2 Whatdo SMEs meanto the Singapore Economy? SMEs is just an imperative piece of the Singapore economy. They contain 92% of aggregate foundations, clichà ©s 51% of the workforce and produce 34% of the aggregate worth included. Nonetheless, their benefit is virtually a large portion of the non-SME foundations. The huge number of low-profit SMEs exists together with a few numbers of more gainful extensive, neighborhood undertakings and remote Mncs. 2 Contribution of SMEs in Singapore The vast majority of the nations saw SMEs as one of the significant that helps to generate a large share of new jobs, promote economic growth, increase competitiveness process and productivity and benefit together with wealth creation. 2.1 Generate a large share of new jobs. More vital than holding the dominant part of occupations in low wage and developing economies, SMEs make a key commitment to the net production of employments, particularly littler and adolescent firms.Work development originates from existing organizations as well as from recently made firms, particularly those that become quickly in the first years of action. These new businesses add up to a generally negligible impact of all organizations. Yet it is assessed that they represent very much a substantial offer of the aggregate employment creation. 2.2 Promote economy growth. Recently reported Singapore is blasting and the Southeast Asian monetary powerhouse extended its general 2013 gauge, expecting a last count of 3.5-4 for every penny GDP development for the year. Anyway the financial news out of Singapore isnt simply a story of colossal progress. Rather, Singapore is experiencing a monetary insurgency, the kind that places small and medium-sized undertakings (SMEs) at the cutting edge of the economy. 2.3 Increase competitive process and productivity. More than 5,600 SMEs were consistent with productivity improvements, capability upgrading and innovation. This was 19% more than 2011. Of these, 72% of the SMEs who had benefitted were small and micro SMEs. Sectoral productivity drives in the retail, food services, food manufacturing and furniture sectors continued to gain traction since its launch in 2011. More than 600 SMEs in these sectors have adopted technologies, redesigned workflows, invested in automation, upgraded capabilities and pursued innovations to improve productivity. 2.4 Wealth Creation â€Å" According to the latest Barclays Wealth Insights report, Singapore is the most fertile environment for millionaires, with 51% of High Net Worth Indiciduals(HNWIs) having accrued their wealth here in less that a decade.† (Lim 2014, P.3) 3 Constrain of SMEs in Singapore SMEs in Singapore got a few shortcomings, for example, low productivity, absence of financing, marketing and promotion and difficulties in lack in managerial capabilities. 3.1 Low Productivity Productivity was negative for six quarters from the final quarter of 2011, and improved marginally in the second and third quarters of a year ago. In a different study directed by the Relationship of Little and Medium Ventures (ASME), 61 for every penny of organizations surveyed demonstrated that they might want to see more activities to build profit. Singapore SMEs likewise need the legislature to expand the PIC plan past the 2014 budgetary year so more organizations can advantage from it. 3.2 Absence of Financing SMEs in the development and extension arrange regularly require a support in financing to accomplish sufficient scale and have to be internationally aggressive. In 2010, the Co-Speculation Program (CIP) was issued to catalyze persistent advance capital for Singapore-based endeavors, through co-contributing with the private segment. The administration put aside $250 million for the first period of the system, of which give or take $160 million has been shipped. This has been effectively catalyzed over $500 million of speculations from private part players, or in excess of three times of the governments cost. In perspective of the critical take-exceptional, we will dispatch the second stage not long from now with the Legislature giving an extra $150 million to match private division speculations. 3.3 Marketing and Promotion In cooperations with different nearby undertakings, we find that SME holders have a tendency to see advertising as a need just for huge companies or consumption that are reasonable just when the organization is doing admirably. These are combined up convictions. Showcasing, both as a solid capacity and as a consumption thing, is fundamental for all organizations substantial, medium or little and adroit advertising is discriminating particularly when the organization is not doing admirably. Sometimes, we will run over a couple of enthusiastic SMEs that are eager to cause uses on showcasing. Sadly, they are frequently restless with the results and they expect prompt money related profits for the consumptions. 3.4 Lack of Managerial Capabilities Managerial issues incorporate those identifying with human assets administration. Help businesses and SMEs in all phases of improvement face the regular issue of drawing in, creating, and holding gifted staff, whether specialists, managers, officials or directors. While MNCs have the ability to enlist and hold the best, supporting commercial enterprises and SMEs cant on account of their constrained money related assets and authoritative practices. The tight work market circumstance in Singapore additionally helps the circumstances, bringing about the cream of the work business sector streaming to the MNCs that offer higher pay, a superior nature of working life, and thoroughly preparing projects. 4 Steps to Strengthen SMEs in Singapore These days, Smes is confronting a considerable measure of issue, such as, absence of managerial value, low productivity, engineering imperative and high cost of creation. So with the goal Smes should fortify their shortcoming this is the few ways that ready to help, such as: 4.1 Priorty Sector Lending The need to hold more and better quality value capital against credits will crush banks ability to loan to SMEs, especially since SME giving accompanies higher expected misfortunes than corporate loaning. Banks will probably move a portion of the expense to SMEs through higher premium rates, along these lines decreasing interest for credit. 4.2 Price Perferences Previously, 15% value inclination was achieved out of SSI units for supplies to Psus/Government bodies. Presently it is adjusted at 20% and in the meantime the prohibition rundown will go. The value inclination is supposed to be settled on exact information which will go about as a measure of help to SSI units for using their ability enough. 4.3 Reformation of Labour Law Multitude of work laws has the potential to a vast degree for moderate development of industry in our nation. Work laws offer a lot of security to work compel by the procurement of least wages, PF, reward, tip and ESI and so on. Then again, the head honchos are forced to look for an earlier authorization actually for getting additional time work from work, on installment and despite common assent. More effective and diligent employees may be suitably compensated, and there ought to be a procurement to deduct wages for evading and sluggishness. Steady work laws are a paramount essential for Indian industry to confront the worldwide rivalry. 4.4 The Opportunity Globalization and liberalization would have made gainful open doors also. Numerous effective and fare arranged a few firms would have picked up out of this improvement. Such open doors ought to go about as a motivating force to abundant a little firm in India to improve their aggressiveness to infiltrate the worldwide business. This could likewise be accomplished by little firms getting to be sellers or subcontractors to remote expansive scale businesses. The pattern is outsourcing of supplies by Tncs and they are constantly vigilant for firms that could supply dependable and quality items. 4.5 Networking – Increase Competitiveness The advancement of between firm linkages is an alternate issue meriting more distinguishing. The expanding vicinity of transnational companies (Tncs) in the nation would open up new open doors for subcontracting/ outsourcing. This is on account of FDI has streamed into commercial ventures, for example, information transfers, transportation, electrical, metallurgical businesses and autos, among others, where opportunities for acquiring subcontracting/ outsourcing are distinguished for little industry. 5 Conclusion Based on the research, later on for SMEs ought to improve social flourishing obliges a need of women asserted SMES, youthful business person, adjust to the future globalization and in conclusion making more legitimacy and unwavering quality items. Firstly, In owning business grants for women following future pioneers who will see their organizations into the following period of development, to contend on the worldwide stage. Besides, Young business person swaying SMEs to be more progress and guaranteeing the budgetary issue too. Ultimately, adjust to globalization and making more unwavering quality and legitimacy items helps SME to be additionally adjusting in the worldwide advance by utilizing advance innovation to deliver a top notch items for society. 6 Reference: AsiaOne Business, (2014). More SMEs seek assistance to increase productivity. [online] Available at: http://business.asiaone.com/sme-central/news/more-smes-seek-assistance-increase-productivity [Accessed 9 Nov. 2014]. Chang, R. (2014). Budget 2014: More support for Singapore companies to raise funds See more at: http://business.asiaone.com/news/budget-2014-more-support-singapore-companies-raise-funds#sthash.SPRx0H0S.dpuf. AsiaOne Business. [online] Available at: http://business.asiaone.com/news/budget-2014-more-support-singapore-companies-raise-funds [Accessed 9 Nov. 2014]. Ho, D. and Lim, L. (2014). SPRING -Marketing is vital for all even for small companies. [online] Spring.gov.sg. Available at: http://www.spring.gov.sg/NewsEvents/ITN/2012/Pages/Marketing-is-vital-for-alleven-for-small-companies-20121123.aspx?skw=smes marketing and promotion [Accessed 9 Nov. 2014]. Ilo.org, (2013). Is small still beautiful?. [online] Available at: http://www.ilo.org/global/about-the-ilo/newsroom/comment-analysis/WCMS_218252/langen/index.htm [Accessed 6 Nov. 2014]. Lim, C. (2014). The Strategy Issue. Volume2 Issue 7. Singapore, p.3. Mediabuzz.com.sg, (2014). Singapore SMEs usher in new era of business productivity. [online] Available at: http://www.mediabuzz.com.sg/asian-emarketing/brand-n-ingameadvertising/2149-singapore-smes-usher-in-new-era-of-business-productivity [Accessed 6 Nov. 2014]. Meti.go.jp, (2014). APEC Internationalization of industrial Science and Technology. [online] Available at: http://www.meti.go.jp/english/apec/apec-isti/ISTI/abridge/sgz/sgzsme05.htm [Accessed 9 Nov. 2014]. Rbi.org.in, (2014). Reserve Bank of India. [online] Available at: http://www.rbi.org.in/scripts/FAQView.aspx?Id=87 [Accessed 10 Nov. 2014]. Sgemployers.com, (2014). www.sgemployers.com | snef. [online] Available at: http://www.sgemployers.com/public/industry/sme21.jsp [Accessed 6 Nov. 2014]. Singapore Business Federation, (2014). SINGAPORE SMEs NEED TO GET THEIR MOJO BACK. [online] Available at: http://www.sbf.org.sg/public/newsroom/details/20131121pr.jsp [Accessed 9 Nov. 2014]. Spring.gov.sg, (2014). SPRING Performance Indicators. [online] Available at: http://www.spring.gov.sg/aboutus/pi/pages/performance-indicators.aspx [Accessed 6 Nov. 2014]. Spring.gov.sg, (2014). SPRING New SME Definition and Launch of New Online Tools and E-Services. [online] Available at: http://www.spring.gov.sg/NewsEvents/PR/2011/Pages/New-SME-Definition-and-Launch-of-New-Online-Tools-and-E-Services-20110322.aspx [Accessed 6 Nov. 2014]. Spring.gov.sg, (2014). SPRING More SMEs Raised Productivity, Innovated and Upgraded Capabilities in 2012. [online] Available at: http://www.spring.gov.sg/NewsEvents/PR/2013/Pages/More-SMEs-Raised-Productivity-Innovated-and-Upgraded-Capabilities-in-2012-20130219.aspx [Accessed 6 Nov. 2014]. Spring.gov.sg, (2014). SPRING SPRING Scholars to Champion SME Growth. [online] Available at: http://www.spring.gov.sg/NewsEvents/PR/Pages/SPRING-Scholars-to-Champion-SME-Growth-20140718.aspx [Accessed 11 Nov. 2014]. U-Wen, L. (2014). BIGGER PRODUCTIVITY PUSH NEEDED FROM SMES. asme. [online] Available at: http://www.asme.org.sg/index.php/news/new/bigger-productivity-push-needed-from-smes [Accessed 9 Nov. 2014]. 6.1 Report: Chane Wube, M. (2010). FACTORS AFFECTING THE PERFORMANCE OF WOMEN ENTREPRENEURS IN MICRO AND SMALL ENTERPRISES. p.22. Lim, C. (2014). The Strategy Issue. Volume2 Issue 7. Singapore, p.3. Nyangori, R. (2014). Factors influencing performance of micro and small enterprises: a case of Kisumu City Bus Park-Kenya. pp.10-11. Oliver Wyman and Fung Global Institute, (2013). Asia Finance 2020 Framing A New Asian Financial Architecture. p.8. Raju, K. (2014). Small and Medium Enterprises (SMEs): Past, Present and Future in India KD Raju. pp.19-20. The Importance of SMEs in the Economy. (2014). p.1. 6.2 Newspaper: Chang, R. (2014). Budget 2014: More support for Singapore companies to raise funds See more at: http://business.asiaone.com/news/budget-2014-more-support-singapore-companies-raise-funds#sthash.SPRx0H0S.dpuf. AsiaOne Business. [online] Available at: http://business.asiaone.com/news/budget-2014-more-support-singapore-companies-raise-funds [Accessed 9 Nov. 2014]. Singapore Business Federation, (2014). SINGAPORE SMEs NEED TO GET THEIR MOJO BACK. [online] Available at: http://www.sbf.org.sg/public/newsroom/details/20131121pr.jsp [Accessed 9 Nov. 2014]. U-Wen, L. (2014). BIGGER PRODUCTIVITY PUSH NEEDED FROM SMES. asme. [online] Available at: http://www.asme.org.sg/index.php/news/new/bigger-productivity-push-needed-from-smes [Accessed 9 Nov. 2014]. 1

Quantitation by Extraction

Quantitation by Extraction Syed Masood Hassan Akbari INTRODUCTION A liquid-liquid extraction phase consists of a component (a) which is to be removed from the feed phase. The addition of a second phase (b) a solvent phase which is immiscible with the feed phase but the component (a) is soluble in both the feed phase and the solvent phase. As it happens the solute (a) is transferred from the feed phase to the solvent phase. After extraction the feed and solvent phases are called the raffinate and the extract phases respectively. Usually one of the two phases is an organic phase while the other is an aqueous phase. Under equilibrium conditions the distribution of the solute (a) over the two phases is determined by the distribution law. After the extraction the two phases can be segregated because of their immiscibility. Component (a) is then separated from the extract phase by distillation and the solvent is then regenerated. Further extractions may be carried out to remove more of the component (a). Once the product of interest has been extracted finally an absorbance reading can be found at its corresponding ÃŽ »max. Figure 1: Shows the chemical structure of trimethoprim. Figure 2: Shows the chemical structure of sulfamethoxazole. This experiment consisted of three main components: The quantification of trimethoprim and sulfamethoxazole in a suspension of Septrin. Interpreting the data gathered and using it in calculating the content of trimethoprim in Septrin. Interpreting the data gathered and using it in calculating the content of sulfamethoxazole in Septrin. EXPERIMENTAL Extraction of trimethoprim and sulfamethoxazole from SEPTRIN. Figure 3: Illustrates a schematic of the entire extraction procedure consisting of trimethoprim and sulfamethoxazole in SEPTRIN oral solution. Sulfamethoxazole (Standard, Sample and Blank prep) Figure 4: Illustrates sulfamethoxazole’s sample preparation. The standard was prepared in the exact manner in a 250ml volumetric flask with using 0.2g of sulfamethoxazole in 50ml 0.1M NaOH and topping up with water. The procedure to follow was the exact same as the sample prep. The blank was prepared in the same manner and water was used along with the reagents outlined above in sample prep. Trimethoprim (Sample and Blank prep) The already extracted bottom layer with chloroform was extracted again using four 50ml quantities of 1M acetic acid and the top layers were combined and washed with 5ml chloroform and the top layer added to a 250ml volumetric flask and filled with 1M acetic acid to the mark. 10ml of this solution was then added to another 100ml volumetric flask and 10ml of 1M acetic acid was also added and topped up with water. The blank was made by using 0.2M acetic acid solution. RESULTS Determining the quantity of trimethoprim and sulfamethoxazole in an oral suspension of SEPTRIN. Table 1: Shows the absorbance values obtained at each respective Ɔºmax for trimethoprim and sulfamethoxazole. Calculations: Trimethoprim The sample had a dilution factor of 1:1000 which meant that there were two dilutions carried out where the suspension was diluted to 250ml, which is a 1:100 dilution. Secondly the sample was diluted too 100ml, which is a 1:10 dilution. These two dilutions steps combined gave a 1:1000 dilution factor. The calculations were carried out as below. 2.5ml in 250ml 1:100 (Dilution ratio) 1:10 (10ml in 100ml) Therefore 1:1000 dilution factor. Absorbance: 0.332 x 1000 = 332 A1%/1cm=204 so 1% solution has 204 absorbance 1%conc = 204 X = 332 332(1)/204 = x X= 1.627% w/v It complies with the compliance limit of (1.44-1.76)% w/v. Sulfamethoxazole 0.2g in 250ml 200mg in 250ml (1:100 dilution ratio) 0.8mg in 1ml (1:50 dilution) 0.016mg in 1ml (1:10 dilution) 0.0016mg in 1ml Sample of sulfamethoxazole absorbance = 0.075 So, 0.0016mg in 1ml = 0.293 And, x = 0.025 0.0250.0016/0.293 = x X = 0.0001365mg in 1ml 0.0001365mg in 1 ml x 50000 = 6.826mg in 1ml 6.826mg in 1ml à ¯Ã†â€™Ã‚   0.06826g in 1ml à ¯Ã†â€™Ã‚   6.826g in 100ml X = 6.826% w/v It does not comply with the compliance limit of (7.4-8.6)% w/v. Trimethoprim and Sulfamethoxazole The concentration of trimethoprim and sulfamethoxazole in 5ml of SEPTRIN were calculated as shown below. Trimethoprim: 1.627% à ¯Ã†â€™Ã‚   1.627g in 100ml So, x in 5ml 100x = 8.135g X = 0.08135g in 5ml SEPTRIN Sulfamethoxazole: 6.826% à ¯Ã†â€™Ã‚   6.826g in 100ml So, x in 5ml 100x = 34.13g X = 0.3413g in 5ml SEPTRIN CONCLUSION The active ingredients in SEPTRIN, trimethoprim 1.627% w/v and sulfamethoxazole 6.826% w/v were segregated by extraction. The concentrations of trimethoprim and sulfamethoxazole in the 2.5ml suspension were calculated to be as stated above respectively. The content of trimethoprim fell within the compliance limit but for the sulfamethoxazole the content fell a bit short of the compliance limit suggesting apparatus malfunction or human error in making up sample. Trimethoprim complies with the limit set out on the BP but for sulfamethoxazole it falls under the limit stated on the BP. QUESTIONS Illustrate the extraction procedure. Support the separating funnel in a ring clamp on a ring stand. Make sure the stopcock of the funnel is closed. Place a stemmed funnel in the neck of the separating funnel. Add the liquid to be extracted, then add the extraction solvent. The total volume in the separating funnel should not be greater than 75% of the funnel volume. Insert a stopper in the neck of the separating funnel. Pick up the separating funnel with the stopper in place and the stopcock closed, and shake it once gently. Point the stem away from your face and slowly open the stopcock to release some build-up of excess pressure, reclose the stopcock and repeat this procedure until only a small amount of pressure is released with it is vented. Shake the funnel vigorously for a minute, release the pressure and then again repeat the step of shaking a few times till there is less pressure and the solutes are at equilibrium between the two solvents. Place the funnel back into the ring and let it rest undisturbed until the layers are clearly segregated. While waiting, remove the stopper and place a beaker under the separating funnel. Carefully open the stopcock and allow the lower layer to drain into the beaker. Drain just to the point that the upper liquid barely reaches the stopcock. The top layer can be left in the separating funnel if further extractions need to be carried out which do need to be carried out. When finished with the separating funnel store the stopper away from the funnel. Explain why sulfamethoxazole is soluble in the alkaline aqueous solution and trimethoprim is not? It is already known that trimethoprim is classified as a benzylpyrimidine and it protentiates the antimicrobial activity of sulphonamides eg., sulfamethoxazole. So trimethoprim has a tendency to form insoluble complexes when combined with sulfamethoxazole in alkaline aqueous media. Write out the chemical reaction which leads to the coloured product. The reaction mechanism above shows the coloured dyeing agent N-(naphthalene-1-yl)ethane-1,2-diamine reacting with the diazonium to form the coloured product. Why is ammonium sulphanate added? What would happen if it was forgotten? AMS is used as a reagent to speed up the chemical reaction if it is not included in the reaction before adding the dying agent then the process will either delay in reaching to its completion or not reach it at all. After extraction of sulfamethoxazole, how is the organic solvent processed? The organic solvent was extracted in four 50ml quantities of 1 M acetic acid. The upper layers were all combined and kept and washed with 5ml of chloroform. The top layer was then dispensed into a 250ml volumetric flask and topped up with 1 M acetic acid. 10ml of this solution was transferred to a 100ml volumetric flask, 10ml of 1 M acetic acid was also added and the flask was topped up with water. A blank was made and the sample from the organic layer was read at 271nm.

Millard Fillmore :: essays research papers

Fillmore, Millard (1800-1874), 13th president of the United States (1850-1853) and the second vice president to finish the term of a deceased president. He succeeded Zachary Taylor at a critical moment in United States history. The Mexican War (1846-1848) had renewed the conflict between the Northern and Southern states over slavery, since it had added new territories to the United States. The debate over whether these territories should be admitted as free or slave states precipitated a crisis that threatened civil war. Much to the relief of Northern and Southern politicians, Fillmore pursued a moderate and conciliatory policy. He signed into law the Compromise of 1850, which admitted one territory as a free state and allowed slave owners to settle in the others. This compromise did not solve the basic problem of slavery but did preserve peace for nearly eleven years. During that time the North gained the industrial power that enabled it to defeat the South when civil war eventuall y came. Fillmore was born in upstate New York in 1800. He was the second child and eldest son in a family of nine. His parents, Nathaniel and Phoebe Millard Fillmore, had moved from Vermont to New York several years before his birth. Young Fillmore did chores on his father's farm, worked as an apprentice in the clothier's trade, and attended local schools irregularly until he was 17. Although the only books in his home were the Bible, an almanac, and a hymnbook, Fillmore managed to educate himself with the help of a village schoolteacher, Abigail Powers. When he was 19, Fillmore began to study law with Judge Walter Wood of Cayuga County. He supported himself by teaching school. When his family moved to East Aurora, near Buffalo, New York, Fillmore continued his study of law and his teaching. In 1823 he opened a law office in East Aurora. Three years later he married Abigail Powers. The couple had two children, Mary Abigail and Millard Powers. In the early years of their marriage, Mrs. Fillmore continued to teach school and to help her husband with his law studies. In 1826, the year Fillmore was married, an incident in western New York set him on the road to the presidency. When William Morgan, a former member of the Masonic fraternal order who had written a book that claimed to expose the order's secrets, disappeared, the rumor spread that he had been murdered by avenging Masons.

On Trying To Understand The Universe and Life :: Biology Essays Research Papers

On Trying To Understand The Universe and Life I sat there in awe. I was in awe at the man's genius. I was in awe of his life. It could be described by no less than miraculous. I was especially shocked at the way the narrator of the movie, A Brief History of Time, related the discovery of his illness. He explained, "The doctors told him that he had about two and a half years to live and only his heart, his lungs, and his brain would eventually remain functional while everything else in his body would turn into a cabbage"(1) The words echoed through my mind, "Only his heart, his lungs, and his brain...". It seemed a terrifying condition to befall a youth in his early twenties. But amazingly, as the story went on, I soon found out that for him, the beginning of his illness marked a turning point from which his life truly begun. And I was at awe at God. Simply at awe. His name is Stephen Hawking. He is considered to be one of the greatest minds of Science. He was diagnosed with Amyotrophic Lateral Sclerosis, ALS, in 1962. He is still alive. He describes his philosophy in life prior to his diagnose in these terms, "My attitude was that nothing was worth an effort"(2) In the movie about his book, A Brief History of Time, it is explained how this philosophy was evident in his scholastic work where, in spite of his genius, he merely maintained an average standing as a student. Besides his diagnosed condition, the movie also points to another factor which reshaped his philosophy and outlook on life. He found love in the heart of a woman, Jane Wilde, who testified, "Without my faith in God, I wouldn't have been able to live in this situation(her husband's condition); I would not have been able to marry Stephen in the first place because I wouldn't have had the optimism to carry me through and I wouldn't have been able to carry on with it"(3) With these two events, things for stephen began to matter and he began to find meaning in putting forth the effort. His accomplishments, exemplified in a Brief History of Time, certainly testify to that. As the story unravels, he not only lived past two and a half years, he lived. He wrote, he studied, he taught, he questioned as his condition progressed; and still he lives.

Business Research Methodology & Quantitative Statistics Essay

The nature of business breed conflicts, obstacles and problems to discover, study and overcome. Every business has problems. They may be small or big problems in small businesses or global corporations, but they are still problems and all require attention. These businesses must address problems by identifying, analyzing and ultimately establishing their own research-based decisions and pursue actions for solutions to the problems. Business supervisors, managers and virtually all realms of leadership are constantly studying and analyzing such business issues. Organizational leadership is intimately involved in different forms of Business Research while they are addressing issues in their decision making processes towards their own business environment for the good of the company. The purpose of this paper is to apply a critical evaluation of the California InterContinental University (CalU) GRC 605, Mini Project for week one in the Business Research Methodology & Quantitative Statistics course (CalU, 2012). This paper will address the importance of business managers embracing the concept that research initiatives are vital to achieve and maintain a competitive business advantage. Discussion in this paper includes general and specific definitions of good and bad forms or research. Finally, this paper will explain the Research Process and provide relevant examples. Explain the Importance of Research The saying goes that those who ignore history are doomed to repeat it. The business leadership may be highly educated and accomplished in their specific industry. However, failure to keep up with business research in the industry they are operating in may result in missed opportunities to increase or even maintain optimum company revenue. Knowledge of business research resources allows business managers to be aware of successes and failures in their industry and can prevent making the same mistakes and enhance the propensity for success. Trends, processes, failures, successes and best practices in their business arena are all salient business insights research may provide. Savvy business managers have a healthy understanding of the virtues of business research and the Research Methods. Training in business research and research methods helps managers become cognizant of the complex nature of business situations. Bougie and Sekaran (2009) suggest the value of research training also enables manager to see through and reject overly simplistic answers to complex issues. Successful business managers study the pros and cons of all potential courses of action before making decisions. They will pursue targeted reviews of other Like-Industry Research findings, which assist these business Decision Makers (DM) in determining if research other than their own Primary findings may be of value as a form of positive or negative implementation for an internal evaluation process and business strategy. Accomplished DMs recognize the importance of Knowledge of Research tools and Methodology in the decision making process. Therefore, successful business DMs pursue the knowledge of research to better control, predict and understand events in their environments to make informed managemen t decisions (Bougie & Sekaran, 2009). Define â€Å"Good† Research Bougie & Sekaran (2009) emphasize the business industry recognized Good Research methods as those, which focus DMs on the multitude of variables in a business problem. Good research follows a focal point on the multi-causality and multi-finality of a given business event to assist in avoiding uninformed, simplistic thoughts of one variable causing another. Successful DMs acknowledge professional research project results originating from their own organizations primary research resources will aide them in the essential action plans with known propensities of success in their decisions. Good research is a bottom-line essential decision-making tool for DMs use (Gorelick, 1993). Good business research involves the use of scientific inquiry into a specific problem, which demands a sound solution for the DMs consideration. Good research requires a logical, step-by-step methodology that is both purposeful and rigorous to ensure a valid end-product. The scientific investigation process and DMs conclusions are essential aspects of an effective problem-solving course of action. Codes of conduct or business research ethics are paramount to the validation of good business research. Data collection, analysis, reporting and dissemination are all salient aspects of good research products, which must be conducted under business research ethical standards recognized in journals and professional publications devoted to the issue of business research ethics. Ethical issues must be addressed with industry standards and superintendence by industry watchdogs for the conduct of business research (Bougie & Sekaran, 2009). Explain the Research Process with Examples Bougie & Sekaran (2009) advance the Hypothetico-deductive research business research model. This Scientific Research method provides a systematic approach for basic and managerial problem solving through a seven-step process. The first step identifies a broad problem area such as a business’s drop in sales, which prompt the DM to initiate the business research project. The second step addresses a general objective of the business research with a well-defined problem statement. This step includes gathering preliminary information through interviews on topics intimately associated with the business environment or conducting a literature review to determine the extent to which the business problem has been exploited. The third step develops a hypothesis by fleshing out, identifying and testing probable variables that are causing the problem, and with gathered information, a prediction is made. A hypothesis follows the frame of an IF/THEN proposal. The primary trait of a hypothesis is that something can be tested and that those tests can be replicated (Zimmerman, 2012). An example of a hypothesis to the problem statement of declining sales may include overpricing as the reason why the business sales are dropping. Determining measures for testing the hypothesis is the fourth step in the business research process. Variables must be measurable or the hypothesis is not testable. The fifth, sixth and seventh steps in the business research method includes; data collection, data analysis and data interpretation. These include selecting the best method for gathering the data, analysis the gathered data to test the hypothesis and finally study the results of the business research project to determine if the hypothesis was correct or refinement of theories and testing is prudent. DMs can then take the results and determine management business decision courses of action (Bougie & Sekaran, 2009). Conclusion Business research is an essential tool that equips organizational leadership with the knowledge that guides informed decisions, grounded in the scientific process to address the business problems. Being educated in the research method process is a hallmark of a modern, successful, professional business manager. Knowing and believing that business problems have problem-solving processes, allow these business managers to proactively identify business problems and address them with strategies to overcome dilemmas before they reach a critical point. Today’s DMs turn to professional business research journals to study problems other industry competitors faced. That along with employing successful business practices, or best methods other industry organizations have used, may work to avoid problems in their own situation. A major factor for the business manager’s consideration is deciphering both good business research project reports and those not validated through the scientific method. In such, leaders may make calculated business decisions with full knowledge of all the risks and advantages involved. Their research knowledge provides sound insight of foreseeable probabilities resulting from the decision – eyes wide open. Further, a well-read, well-trained business manager is savvy to internal and external vested interests that may attempt to exert or advocate their decision preferences, which may be flawed or prejudiced. Practical experience and formal, scientific education and training in the business research field provide the business manager with the best possible combination for calculated, informed senior business decision making (Bougie & Sekaran, 2009). References Bougie, R., Sekaran, U. (2009). Research and markets: Research Methods for Business – A skill Building Approach. (5th Ed). John Wiley & sons Ltd Publishing. California InterContinental University. (2010, Jun 16). Study Guide, GRC 605, Research and Markets: Research Methods for Business – A Skill Building Approach, 5th ed. Gorelick, D. (1993). Good Research has Obvious – and Not So Obvious Benefits. Marking News, 27(19), 16-16. Retrieved 14 January 2013 from http://search.proquest.com/docview/216424702?accountid=35996 Zimmerman, Kim Ann. â€Å"What is a Scientific Hypothesis? | Definition of Hypothesis | LiveScience .† Science News – Science Articles and Current Events | LiveScience . Live Sciences, 10 July 2012. Web. 17 Jan. 2013. .

Webster Clay Calhoun Comparison Essay

Henry Clay, John C. Calhoun, and Daniel Webster dominated national politics from the end of the War of 1812 until their deaths in the early 1850s. Although none were ever President, they had a huge impact in Congress. Their impact outweighed the impact of any of the presidents of that era, with the exception of Andrew Jackson. There was one issue effecting the nation throughout their time in power — slavery. They were all successful in keeping peace in America by forging a series of compromises. The next generation's leaders were not so successful.The Gold Rush led to the rapid settlement of California which resulted in it quickly becoming the 31st state. Southerners recognized that California would be the 16th free state, giving the non-slave holding states the Senate, and they were already holding the House of Representatives. At this time, Texas was claiming land in New Mexico. As a slave state, any expansion of the boundaries of Texas would be expanding slavery. Northerner s were opposed. The north was also appalled at the ongoing practice of slavery in the nation's capital. The lines were drawn as Clay, Calhoun and Webster took the stage. Henry Clay had brokered compromises before.When the Congress was divided in 1820 over the issue of slavery in the Louisiana Territory, Clay set forth the Missouri Compromise. When South Carolina nullified the tariff in 1832, Clay saved the day with the Compromise Tariff of 1833. With the new dispute in the nation he put forth a set of eight proposals that he hoped would work. John C. Calhoun took to the floor next. Although he was sick and dying he sat in the Senate chamber as his speech was read. The compromises would betray the south, he claimed. Northerners would have to agree to federal protection of slavery for the south to feel comfortable remaining in the Union.His words foreshadowed the trials the Union that would soon experience.. Daniel Webster spoke three days after Calhoun's speech. He asked northerners to accept southern demands for the sake of Union. Withdrawing his former support for the Wilmont Proviso, he hoped to persuade people to move closer to Clay's proposals. Although there was no immediate deal, his words impacted Congressmen as they debated into the summer. By 1852, Clay, Calhoun, and Webster had all died. They left behind a huge impact on the nation. They united their country in a way no learned to follow behind them could.